Contraception Flashcards
2 general contraceptive mech’s
- inhibit formation and release of egg
- mechanical, chemical, or temporal barrier b/w sperm and eggq
Hormonal contaceptives
- pills
- injectable
- implantable
- IUD
- contraceptive patches
- contraceptive rings
Injectable
-depo medroxyprogesterone acetate (DepoProvera)
Implantable
-etonogestrel rod implant (Nexplanon)
IUD
- levonorgestrel (Mirena
- Skyla
- Liletta
Contraceptive patches
-OrthoEvra
Contraceptive rings
NuvaRing
Oral Contraceptives- combo- moa
- suppress GnRH- suppression of FSH and LH
- progesterone- major player- suppress LH and ovulation, thicken cervical mucus, creates an unfavorable atrophic endometrium for implantation
- estrogen- improves cycle control- stabilize endometrium, allows less breakthru bleeding
Progesterone- consider what?
androgenic effect!!
Progestin-only oral contraceptives (mini-pill)- moa
- make cervical mucous thick and impermeable
- ovulation continues in 40%
- used in breastfeeding women and women how have a contraindication to estrogen!!
Oral contraceptives- benefits
- menstrual cycle regularity
- improve dysmenorrhea
- dec risk of iron def anemia
- lower incidence of endometrial and ovarian cancers
oral contraceptives- SE’s
- breakthru bleeding- in 1st 3 months
- amenorrhea
- mild SEs- bloating, breast tenderness, nausea, fatigue, HA
oral contraceptives- serous SE’s
- venous thrombosis!!
- PE!!
- cholestasis and gallbladder dz
- stroke and MI
- hepatic tumors
Transdermal patch
(estrogen and progesterone)
- for 3 wks
- greater risk of thrombosis
vaginal ring
(estrogen and progesterone)
-for 3 wks
who CANT use oral contraceptives?
- > 35 yo and smoke cigarettes
- hx of thromboembolic event
- CAD, cerebral vascular dz, CHF, migraine with aura, uncontrolled HTN
- liver dz/tumors
Depot Medroxyprogesterone Acetate (Depo Provera)
- IM injection every 11-13 wks
- maintains contraceptive level of progestin for 14 wks
- thickens cervical mucus, decidualization of endometrium, blocks LH surge and ovulation
Depot Medroxyprogesterone Acetate (Depo Provera)- bone effects?
- alterations of bone metabolism (dec estrogen levels)
- reversible after discontinuation
Depot Medroxyprogesterone Acetate (Depo Provera)- SEs
- irregular bleeding!- menses can take up to a yr to regulate after discontinuation
- weight gain (hungry)
- exacerbation of depression!!!
Depot Medroxyprogesterone Acetate (Depo Provera)- contraindications
- pregnancy
- vaginal bleeding
- malignancy of breast
- thromboembolic events
- liver dz
LARCs
-implants and IUDs
Implant
etonogestrel- Nexplanon
Nexplanon
- radiopaque, implant- etonogestrel
- used for 3 yrs
- moa- thickens cervical mucus, inhibits ovulation
Nexplanon- SEs
- irregular vaginal bleeding
- HA
- weight inc
- breast pain