contraception Flashcards
latex condoms should not be used w/ ___
oil lubricants
do diaphragms and cervical caps req spermicide use?
yes
most effective barrier method if used perfectly
condom 2% (13% typical use)
estrogens suppress ___
FSH
progestins suppress ___
LH mid cycle surge
which estrogen is pharmacologically active?
ethinyl estradiol
estrogen in OCP should be below ___ to minimise SEs
<35mcg
AEs: HA, nausea, breast tenderness
estrogens
AEs: Acne, hirsutism, weight gain, fatigue, depression
progestin
low androgenic progestins
Ethynodiol, norgestimate, desogestrel, drospirenone, dienogest
progestin w/ antiandrogenic and antimineralcorticoid activity
drospirenone
progestin that can cause hyperkalemia
drospirenone
progestin w/ highest risk of clots
drospirenone
OCPs decrease risk for which cancers?
endometrial, ovarian
progestin indicated for PMDD
drospirenone
OCPs helpful for which conditions?
benign breast dz, ovarian cysts, endometriosis, acne
change to make if OCP pt complains of decreased libido
increase estrogen or consider vaginal ring
change to make if pt OCP pt complains of weight gain
decrease estrogen, or switch to progestin w/ lower androgenicity
change to make if pt OCP pt complains of high triglycerides
switch to progestin w/ lower androgenicity
change to make if pt OCP pt complains of spotting
can increase estrogen, wait a few months, counsel to take pill at same time QD
main risks of OCPs
CV events, HTN, VTEs, STIs, gallbladder dz, hepatic tumors, cervical CA
combined OCP contras
Primarily d/t estrogen component
* Hx of DVT/PE
* CVA/CAD/Ischemic heart dz
* DM w/ vascular dz
* Breast cancer
* Liver adenoma, hepatitis, cirrhosis
* Migraine HA w/ aura - CVA risk is increased and would be difficult to differentiate
* Surgery w/ prolonged immobilization
* >35 years old AND smoking >1-5 cigarettes/day
* BP >160/100
warning sign counseling for OCPs
stop med and seek care immediately if: Abdominal pain (severe)
* Chest pain (severe), cough, SOB
* Headache (severe), dizziness, weakness, or numbness
* Eye problems (vision loss or blurriness), speech problems
* Severe leg pain (calf or thigh)
stay on OCP for __ months before changing
3
missed dose interval for progestin only pills
3 hours
Advantages = decreased menstrual blood loss, decreased cramps, decreased risk of VTE, preferable in lactation
progestin only pills
higher failure rates: combined or progestin only pills?
progestin only pills
only abx w/ a true documented pharmacokinetic interaction
rifampin
DI for OCPs
abx
Phenobarbital, phenytoin, carbamazepine (induce metabolism)
Ritonavir-boosted protease inhibitors (HIV drug)
warfarin (increases clotting)
st johns wort (induces metabolism)
thyroid products
is the patch good for obese women?
no
if patch comes off for >24 hrs…
use back up method until on skin X 7d
vaginal ring decreases which SEs?
less irritability, depression, acne, nausea, and emotional lability
Medroxyprogesterone acetate (Depo-Provera) type of BC
IM or SQ injection Q 12-14 wks
indications for Medroxyprogesterone acetate (Depo-Provera)
lactating, can’t take estrogen, seizures
return to fertility after Medroxyprogesterone acetate (Depo-Provera)
18 months
BBW: Medroxyprogesterone acetate (Depo-Provera)
significant decrease in BMD, possibly irreversible, increases w/ duration of use
* Long term use (>2 years) only recommended if other methods are inadequate or
symptoms of endometriosis return after discontinuation
* Recommend calcium, vitamin D, and weight bearing exercise
which BC can cause decidual cast?
Medroxyprogesterone acetate (Depo-Provera)
most effective BC
IUDs, implants
CI for hormonal IUD Levonorgestrel (Mirena, Skyla, Liletta)
Undiagnosed uterine bleeding, current or hx of breast carcinoma, acute PID or STI, pregnancy
plan B should be taken w/in ___ hrs
72, but can be up to 5 days
plan B ASW fental malformations?
no
emergency contraceptive ASW fetal malformations
Ulipristal (Ella)
Ulipristal (Ella) should be taken w/in ___ days
5
most effective form of emergency contraception
copper IUD inserted w/in 5 days
best emergency contraception for obese women
copper IUD