Contact and Occupational Dermatology Flashcards
what constituent of the TRUE Test is used at near irritant concentrations?
formaldehyde. Generally you can ignore questionable macular reactions
in addition to the standard panel, what additional allergen should a hairdresser be tested to
glyceryl thioglycolate
this is an important allergen in acid permanent wave solutions
what component of the TRUE test is often frequently associated with positive reaction to neomycin sulfate
Bacitracin. they are not related chemically, so his is probably more accurately called co-sensitization
why should care be taken in cases of suspected contact urticaria to Bacitracin
can have anaphylaxis
what are the big ingredients of the black rubber mix?
what are these chemicals used for?
generally phenylenediamines
CPPD
IPPD
DPPD
these are used to prevent drying and cracking of rubber products (including tires), they generally turn things black hence their use with black rubber.
what cross-reactivity should you look for with black rubber mix?
the phenylenediamines (CPPD, IPPD, DPPD) can cross react with the hair dye base p-phenylenediamine
What is 2-bromo-2-nitropropane-1,3-diol’s other name, and what is it used in?
bronopol
preservative with anti-pseudomonal activity used in cosemtics, topical medications, and industry
formaldehyde donor, but not all people allergic to this are allergic to formaldehyde
caine mix (benzocaine)
a mixture of benzocaine, tetracaine, and dibucaine is used in TRUE test. If they are allergic have to test further to individual consitutents
cross sensitization common to PABA and PABA ester containing sunscreens, permanent hair dye (p-phenylenediamine), diruetics like HCTZ, sulfonylureas, sulfa antibiotics, pocainamide (important cardiology drug)
What is in the carba mix and what are these chemicals used for
1,3 - Diphenylguanidine (DPG)
Zinc diethyldithiocarbamate (ZEC)
Zinc dibutyldithiocarbamate (ZBC)
these are used in the production of rubber for gloves, adhesives, clothing, condoms.
what mix on the TRUE test (pertaining to producing rubber) are tested at near-irritant concentrations?
carba mix
what are the ingredients in the carba mix specifically used for
the two carbamates are used in consumer rubber products
the DPG is used in industrial rubber products
what is cobalt dichloride used in
used to make hard alloys. used in everything from artificial joints, dental implants, jet engines, pottery.
if you are sensitized to cobalt what else are you probably sensitized to?
nickel (especially women)
chromate (men - probably due to industrial exposures)
what is a different-looking patch reaction that can be seen with cobalt
false positive result with tiny purpuric-appearing macules and papules
what is colophony (rosin)?
yellow natural residue from distiling off volatile oil from oleoresin obtained from confireous trees
colophonium is the name used on cosmetics
what is the allergen in unmodified colophony (rosin)?
abietic acid
What is disperse blue dye 106 used for
primarily used to dye synthetic fabrics, especially polyesters
What is diazolidinyl urea used for
formaldehyde-releasing preservative
thus, patients allergic to this are often allergic to other formaldehyde-releasers
epoxy resin - what is it used for
what is the most common allergen of this type
adhesive systems, glues
diglycidylether of bisphenol A
are HIGH or LOW molecular weight epoxy resins sensitizing
cured or uncured?
low
uncured epoxy resin is sensitizing.
ethylenediamine - what is used for
especially used as a stabilizer for creams, particularly old-school mycolog and current generic versions of Nystatin.
also found in aminophylline
does EDTA cross-react with ethylenediamine
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