Chapter 2. Cells Involved in Immune Responses Flashcards
1
Q
what is a granuloma
A
many macrophages fuse to form granulomas to wall off a pathogen that they can’t clear. this is prompted by TNFalpha. sarcoidosis - noncaseating tuberculosis - caseating
the image shows a “gaucher cell”, a macrophage with a “crumpled tissue” appearance
2
Q
In what disorder can EBV be fatal
Where is the genetic defect in this disorder
A
HLH is often a fatal consequence for boys with X-linked lymphoproliferative syndrome
SH2D1A (encodes SAP protein)
3
Q
what is the difference between HLH and MAS
A
MAS is basically HLH but due to a chronic rheumatoid disease
