lectures

Question 1

what proportion of lymphocytes are T cells?

Answer 1

2/3

Question 2

Of lymphocytes, what proportion are CD4?

Answer 2

2/3

Question 3

How are NK cells identified on flow?

Answer 3

CD16+ CD56+

Question 4

In what clinical scenario do we care about IgG subclass deficiency?

Answer 4

patients with IgA deficiency and recurrent infections may have a decrease in IgG2 which can be clinically relevant

Question 5

What age do we expect kids to start mounting response to polysaccharides?

Answer 5

24 months

Question 6

by what age should every child have a response to candida antigen

Answer 6

12 months

Question 7

in addition to sinopulmonary infections, what other infections are more common in kids with humoral issues

Answer 7

giardia, enterovirus

Question 8

what is effect of HLA on growth

Answer 8

none

Question 9

In contrast to XLA, where is there is no lymph tissue on palpation, what is the case in Omenn’s syndrome

Answer 9

increased

Question 10

What mutations are associated with Job Syndrome

Answer 10

STAT3, DOCK8

Question 11

NEMO is associated with what

Answer 11

NFkappaB, X linked, ectodermal dysplasia, conical teeth

Question 12

what is a normal ANC? what is a severe deficiency?

Answer 12

normal >1500, severe <500

Question 13

what is a normal ALC in adults? in babies?

Answer 13

normal >1500 adults, >3000 newborns

Question 14

what IgG level is low enough to diagnose CVID (in addition to having low IgA and/or IgM) and low antibody response

Answer 14

<450

Question 15

What are the lab findings in SCID

Answer 15

low absolute lymphocyte count (<1500), very low or absent T lymphocytes (<300), low or normal Igs, absent antibody responses, low mitogen stimulation (<10% of normal)

Question 16

review SCID phenotyping/genotyping

Answer 16