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Oral Pathology > Connective Tissue Lesions > Flashcards

Connective Tissue Lesions Flashcards

1
Q

What does lymphangioma look like?

A

Vesicle like if superficial Can appear submucosal when deeper.

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2
Q

Leiomyoma Characteristics

A

Benign tumor of smooth muscles Rare in oral cavity Any age and slow growing

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3
Q

Congenital Epulis predilection

A

BIG female predilection

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4
Q

Neurofibroma DDx

A

Submucosal nodules Traumatic fibroma Granular cell tumor Lipoma Macroglossia Lymphangioma Amyloidosis Myxedema Acromegaly

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5
Q

Granular Cell Tumors Histo

A

Sheet of large cells with granular eosinophilc cytoplasm Pseudoepitheliomatous hyperplasia Granular cells stain with S-100

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6
Q

Schwannoma Appearance

A

Slow growing and submucosal Common locations → tongue, palate, lips NO PAIN, unless compressing a nerve

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7
Q

Schwannoma Histo

A

Interestingly, no nerve tissue in the lesion. As lesion grows, nerve is pushed aside. Antoni Type A and Type B patterns Type A: LOOOOONG spindle shaped cells; paralleling and palisading Type B: MIcrocystic arrangement of cells

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8
Q

Traumatic neuromas are associated with pain what percentage

A

50% Tenderness to severe pain.

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9
Q

MEN characteristics

A

Autosomal dominant MEN 1 and MEN 2A/B MEN 2B has mucosal neuromas (only one with ORAL manifestations) and medullary carcinoma of thyroid gland

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10
Q

Cause of traumatic neuroma

A

Injury to a peripheral nerve that causes inflammation and scarring to the area.

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11
Q

DDx Congenital Epulis

A

Gingival cyst Neuroectodermal tumor of infancy Rhabdomyosarcoma

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12
Q

Origin of neurofibroma

A

Benign tumor of nerve tissue origin

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13
Q

Rhabdomyosarcoma Characteristics

A

Most common malignant neoplasm of skeletal muscles origin 40% occur in the head and neck Common in children (1st decade)

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14
Q

Traumatic Neuroma Characteristics

A

Not a TRUE neoplasm Occurs with trauma, but also cases without trauma present

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15
Q

Myositis Ossificans histo

A

Central proliferating osteoblasts Maturation and organized osseous structures

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16
Q

What is this

A

Granular cell tumor

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17
Q

Cause of MEN

A

Mutation on RET oncogene Leads to neoplasms arising in endocrine tissues

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18
Q

TX Congenital Epulis

A

Excision

19
Q

What neoplasms involved with MEN

A

Parathyroid hyperplasia or
adenoma

Multiple pheochromocytomas

Medullary carcinomas of the thyroid

20
Q

Neurofibromatosis histo

A

Composed of Schwann cells, fibroblasts, perineural cells Positive for S-100

21
Q

DDx Granular Cell Tumors

A

Neurofibroma Schwannoma Fibroma Lipoma

22
Q

Traumatic Neuroma TX

A

Excision

23
Q

When do mucosal neuromas of MEN occur

A

Usually early in life

24
Q

Traumatic Neuroma Histo

A

Nerve fibers in discrete bundles

25
Q

What is cystic hygroma

A

Lymphangioma of the neck. Large swelling that can be life threatening

26
Q

Neurofibromatosis Appearance

A

Multiple nodules on skin. 25% of NF will have nodules in the mouth

27
Q

Where lymphangioma occur

A

The tongue most commonly

28
Q

Schwannoma etiology

A

Benign neoplasm of Schwann cells of the neural sheath

29
Q

Congenital Epulis Appearance

A

Usually present at birth Present on the anterior maxilla alveolar crest commonly, Also on mandible (alveolar crest)

30
Q

What bone changes are involved with neurofibromatosis?

A

Blunderbuss IA canal

Cortical erosion or intrameduallary erosion

31
Q

Granular Cell Tumors Appearance

A

Can have a yellowish surface color Usually a single, submucosal mass

32
Q

Location of neurofibroma

A

tongue, buccal mucosa, palate, vestibule If on tongue, macroglossia possible

33
Q

Myositis Ossificans Characteristics

A

Reaction lesion of skeletal muscles with intramuscular inflammation with ossification Two forms: progressive systemic and focal single `

34
Q

what is this

A

congenital epulis

35
Q

Congenital Epulis Histo

A

Similar to granular cell tumor, but NO pseudoepitheliomatous hyperplasia

36
Q

Lipoma Characteristics

A

Benign tumor of mature fat

37
Q

Appearance of neurofibroma

A

Firm nodule that will be color of normal mucosa

38
Q

Oral involvement of MEN 2B

A

Mucosal neuromas Appear as small, discrete nodules on the labia, larynx, and tongue, BM

39
Q

Another name for congenital epulis

A

congenital gingival granular cell tumor

40
Q

Cause if neurofibromatosis

A

An autosomal dominant inherited disease

41
Q

What enlargements can occur with lymphangioma

A

Macroglossia and macrocheilia

42
Q

Leiomyoma appearance

A

Firm nodule with normal mucosa

43
Q

Characteristics of neurofibromatosis

A

Cafe-au-lait spots Well-defined border (Coast of California) Multiple neurofibromas Lisch nodules in eyes Axillary frecking Skeletal deformities

Oral Pathology (5 decks)

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