connective tissue Flashcards
1
Q
1. Typical GAGs in a human being are: Select one or more: a. Dermatain-sulfate b. Chondroitin-sulfate c. Keratin-sulfate d. Heparin
A
a/b/c/d
2
Q
2. Which are cell binging proteins? Select one or more: a. Collagen b. Laminin c. Elestin d. Fibronectin
A
b/d
3
Q
- The statement(s) about the toughness of collagen:
Select one or more:
a. With aging the number of cross-links between the molecules are increasing
b. The collagen cannot be stretched
c. The toughness of collagen is mainly depending on its triple helix structure
d. With aging the collagen will be more elastic
A
a/b
4
Q
4. Typical location of heparin-sulfate is/are: Select one or more: a. Cell surface b. Basement membranes c. Cornea d. Cartilage
A
a/b
5
Q
- True statement(s) about the glucosaminoglycans and proteoglycans:
Select one or more:
a. They filter the macromolecules
b. Because of their positive charge they cannot move closer when compressed
c. They filter the tumor cells
d. They hold water
A
d
6
Q
- True statement(s) about proteoglycan (PGs) in connection with wound healing:
Select one or more:
a. In wound healing epithel cells synthetize dermatan and chondrotin-sulfate
b. The amount of PGs is decreasing via remodeling
c. The amount of PGs in scar is decreasing with aging
d. The proteoglycan synthesis is increased in the first 3 weeks
A
b/d
7
Q
- True statement(s) about the synthesis of collagen:
Select one or more:
a. Van der Waals bounds are between the collagen fibrils
b. The procollagen triplexes are leaving the cell via exocytosis
c. Vitamin C is needed to the normal function of procollagen peptidases
d. The final triple helix formation is happening in the extracellular space
A
b
8
Q
8. Which cells are not structural elements of the connective tissue? Select one: a. Chondroblasts b. Neurons c. Smooth muscle cells d. Endothel cells
A
b
9
Q
- True statement about the structure of collagen:
Select one:
a. Its molecular weight is around 200-300 kD
b. Collagen’s basic unit is coiled into a left handed helix molecule
c. Collagen is 10% of total protein in a newborn baby
d. Collagen is synthetized from the preprocollagen molecule
A
b
10
Q
- True statement(s) about the glucosaminoglycans linkage to the protein core:
Select one or more:
a. The core protein is rich in serine in these places
b. The trisaccharide unit consist of 2 galactose and a xylose molecule
c. With the statements above is possible that the proteoglycans have a structure like a
bottle brush
d. There is a specific trisaccharide unit
A
a/b/c/d
11
Q
- True statements about the exctracellular matrix (ECM), except:
Select one:
a. anulus fibrosus and nucleus pulposus are connective tissues
b. it helps for the inflammatory cells to spread the inflammation
c. macromolecules are filtered by the ECM
d. it is a filler material to cushion organs
A
a
12
Q
- True statements about the Marfan syndrome:
Select one or more:
a. among artists and athletes there is an increased number of patients with Marfan
syndrome than in the normal population
b. no gender predilection is known
c. it is pan-ethnic
d. its inheritance is autosomal recessive
A
b/c
13
Q
13. The most frequent amino acids in collagen are: Select one or more: a. alanine b. glycine c. proline d. Hydroxiproline
A
b/c/d
14
Q
14. Dermatan-sulfate is mainly present in: Select one or more: a. skin b. heart valves c. cartilage d. blood vessels
A
a.d
15
Q
- True statement about Marfan syndrome:
Select one:
a. A Marfan syndrome patient can have an average height
b. healthy lifestyle is good prevention for Marfan syndrome
c. Marfan syndrome is an acquired disorder
d. Marfan syndrome is a disease of modern civilization
A
a
16
Q
16. In glucosaminoglycan molecules the disaccharide units are containing a: Select one: a. N-glucuronidated hexosamine molecule b. N-methylated hexosamine molecule c. N-acetylated hexosamine molecule d. N-ethylated hexosamine molecule
A
c
17
Q
17. Dermatan sulfate is present in: Select one or more: a. ligaments b. meniscus c. cartilage d. joint capsule
A
b/d
18
Q
- True statement(s) about the glucosaminoglycans:
Select one or more:
a. they are rigid
b. they are located on the surface of the cells
c. they provide the structural integrity of the cells
d. because of their low compressibility they are ideal for lubricating the joints
A
a/b/c/d
19
Q
19. Prolyl-lysil hydroxylase enzyme requires: Select one or more: a. iron b. O2 c. alpha-ketoglutarate d. ascorbic acid
A
a/b/c/d
20
Q
20. Hyaluronates are mainly present in: Select one or more: a. vitreous humor b. cartilage c. bones d. synovial fluid
A
a/d
21
Q
- True statements about the glucosaminoglycan molecules:
Select one:
a. their basic units are monosaccharides
b. they play an important role in the synthesis of collagen
c. they bind to a core protein molecule
d. they are not important in wound healing
A
c
22
Q
- The genetic background of Marfan syndrome is:
Select one or more:
a. Marfan syndrome patients always have a fibrillin-1 gene mutation
b. the mutation affects the fibrillin-1 gene
c. 75% of patients have affected parents
d. 25% is because of new mutation
A
b/c/d
23
Q
- True statements about the hyaluronic acid:
Select one or more:
a. it is the largest glucosaminoglycan
b. its occurrence is about 10-20% in skin
c. its occurrence is about 50-60% in aorta
d. it is present in all connective tissues
A
a/b/d
24
Q
24. Which are cell binding proteins? Select one or more: a. elastin b. collagen c. laminin d. fibronectin
A
c/d
25
```
25. Collagen disorders can happen because of:
Select one or more:
a. excessive collagen content
b. insufficient collagen extent
c. insufficient breakdown of collagen
d. abnormal synthesis of collagen
```
a/c/d
26
26. True statement about the elastin:
Select one:
a. it plays an important role in the structure of bones and cartilages
b. the ability of stretch depends on the desmosine cross-links
c. it is synthetized from a preproelastin molecule
d. its synthesis is totally different from the synthesis of collagen
b
