CONGENITAL NEUTROPHIL ABNORMALITIES Flashcards
A GROUP OF DISORDER OF OXIDATIVE METABOLISM AFFECTING THE CASCADE OF EVENTS REQUIRED FOR H2O2 PRODUCTION OF PHAGOCYTES
- affects the neurtophil microbial action
- impairment of NADPH production
chronic granulomatous disease
positive result of chronic granulomatus disease
blue precipitate
rpresents a qualitative disorder of neutrophils
- rare familial disorder
- neutrophils a giant granules
chediak higashi sydrome
most common neeutrophil abnormality
- deficinet of myeloperoxidase
- mild to moderate defect in bacterial killing
- maked defect in fungal killing in vitro
myeloperoxidase deficiency
associated poor neutrphil function
diabetes mellitus
abnormaities in the cemotactic movement
lazy leukocyte syndrome
job’s syndrom
a rare ondition inherited as an autosomal recessive trait.
-LEUKOCYTE ADHESION DEFICIENCY
COMPLMENT RECEPTOR 3 DEFICIENCY
ATTACKS INVADERS INSIDE THECELLS
CELL MEDIATED
ATTACKS INVADERS OUTSIDE THE CELLS
HUMORAL
TYPES OF ADAPTIVE IMMUNITY: (4)
-NATURALLY ACQUIRED ACTIVE IMMUNITY
ARTIFICIALLY ACQUIRED ACTIVE IMMUNITY
NATURALLY ACQUIRED PASSIVE IMMUNITY
ARTIFICIALLY ACQUIRED PASSIVE IMMUNITY
SITE OF MATURATION OF t-CELLS AND B CELLS
very active central lymphoid organs amd thymus
primary lymphoid organs
site of proliferation and differentiation of t cells and b cells
- peripherall lymphoid organ, platelets, spleen, thymus, GALT
- traappning sites and bystanders of T&B cells
- site of phagoctosis, lymphokines
secondary lymphoid organs
whatt are the primary lymphoid organs
bone marrow and thymus
secondary lymphoid organs (5)
lymph nodes tonsils appendix peyer's pached adenoi
chief lymphocytes in blood and lymph
t cells
marker of t cells
terminal deoxynucleotidyl transferase (TDT)
CD$ - regulatory
CD*
effector
t cell subsets
t helper cells (CD4)
T suppressor cells (CD8)
T cytotoxic cells (IL@)
T delayed hypersensitivity
t cells developments. enumerate
-double negative double positive mature t cells activated te cells sensitized t cells t cell receptor
precursor of lymphocyte
thymocyte
starting of t cells
CD4 and CD8
CD4- and CD8-
double negativ: thymocytes
CD4 and CD8+
double positive
either CD4 or CD8 is positive
-CD4+ = MHC»_space;?
CD8+ MHC class?
mature t cells class 2 class 1
tcells binds to IL-1
activated t cells
t cells that secrete lymphokines
sensitized te cells
sheep RBC receptor
CD2
part of t cell Ag- receptor complex
CD3
classical t cell marker
CD2
receptor of MHC class 2 molecule (Th)
CD4
receptor of MHC class 2 molecule (Ts and Tc)
CD8
receptor of IL-2
CD25
receptor of pro b cell
CD19 and CD45
receptor for EBV
CD2
receptor for b cells
surface immunoglobulin (SmIg)
they help b cell to develop into antibody-producing plasma cells
CD4
they help CD* cells to become activated cytotoxic tcells
CD4
they help macrophages effect delayed hypersensitivity
CD4
help activate cytotoxic t cells
Th 1
perform the B cell helper function
Th2
precursor cell in Ab production
b cells
primary follicles and red pulp of spleen
b cells
what are the the b cells development
-pro b cells
-pre b cells
-immature b cells
mature b cells
-activated b cells
-plasma cells
successful rearrangements of heavy chains
pre b cells
markers of pro b cells
CD19,
CD45R
CD43
CD24
synthesis of the heavy chain part of the antibody molecule
-surrogate light chain
pre b cells
completion of light chain rearrangement commits
immature b cells
surface proteins of immature b cells
CD2
CD40
MHC class 2 molecule
IgM and IgD is present on the surface
Mature b cells
exhibit identiffying marers that include CD25, which is found on both activatedde T and B cells and acts as a receptor fr interleukin-2
activated b cells
antibody production
plasma cells
activated by saller amounts of antigen and require less costimulation tha do naive, unactivated t cells
memory cells
