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immunology & serology > CONGENITAL NEUTROPHIL ABNORMALITIES > Flashcards

CONGENITAL NEUTROPHIL ABNORMALITIES Flashcards

1
Q

A GROUP OF DISORDER OF OXIDATIVE METABOLISM AFFECTING THE CASCADE OF EVENTS REQUIRED FOR H2O2 PRODUCTION OF PHAGOCYTES

  • affects the neurtophil microbial action
  • impairment of NADPH production
A

chronic granulomatous disease

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2
Q

positive result of chronic granulomatus disease

A

blue precipitate

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3
Q

rpresents a qualitative disorder of neutrophils

  • rare familial disorder
  • neutrophils a giant granules
A

chediak higashi sydrome

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4
Q

most common neeutrophil abnormality

  • deficinet of myeloperoxidase
  • mild to moderate defect in bacterial killing
  • maked defect in fungal killing in vitro
A

myeloperoxidase deficiency

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5
Q

associated poor neutrphil function

A

diabetes mellitus

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6
Q

abnormaities in the cemotactic movement

A

lazy leukocyte syndrome

job’s syndrom

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7
Q

a rare ondition inherited as an autosomal recessive trait.

-LEUKOCYTE ADHESION DEFICIENCY

A

COMPLMENT RECEPTOR 3 DEFICIENCY

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8
Q

ATTACKS INVADERS INSIDE THECELLS

A

CELL MEDIATED

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9
Q

ATTACKS INVADERS OUTSIDE THE CELLS

A

HUMORAL

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10
Q

TYPES OF ADAPTIVE IMMUNITY: (4)

A

-NATURALLY ACQUIRED ACTIVE IMMUNITY
ARTIFICIALLY ACQUIRED ACTIVE IMMUNITY
NATURALLY ACQUIRED PASSIVE IMMUNITY
ARTIFICIALLY ACQUIRED PASSIVE IMMUNITY

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11
Q

SITE OF MATURATION OF t-CELLS AND B CELLS

very active central lymphoid organs amd thymus

A

primary lymphoid organs

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12
Q

site of proliferation and differentiation of t cells and b cells

  • peripherall lymphoid organ, platelets, spleen, thymus, GALT
  • traappning sites and bystanders of T&B cells
  • site of phagoctosis, lymphokines
A

secondary lymphoid organs

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13
Q

whatt are the primary lymphoid organs

A

bone marrow and thymus

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14
Q

secondary lymphoid organs (5)

A 
lymph nodes
tonsils
appendix
peyer's pached
adenoi
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15
Q

chief lymphocytes in blood and lymph

A

t cells

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16
Q

marker of t cells

A

terminal deoxynucleotidyl transferase (TDT)

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17
Q

CD$ - regulatory

CD*

A

effector

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18
Q

t cell subsets

A

t helper cells (CD4)
T suppressor cells (CD8)
T cytotoxic cells (IL@)
T delayed hypersensitivity

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19
Q

t cells developments. enumerate

A 
-double negative
double positive
mature t cells 
activated te cells
sensitized t cells
t cell receptor
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20
Q

precursor of lymphocyte

A

thymocyte

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21
Q

starting of t cells

A

CD4 and CD8

22
Q

CD4- and CD8-

A

double negativ: thymocytes

23
Q

CD4 and CD8+

A

double positive

24
Q

either CD4 or CD8 is positive
-CD4+ = MHC&raquo_space;?
CD8+ MHC class?

A 
mature t cells
class 2
class 1
25
Q

tcells binds to IL-1

A

activated t cells

26
Q

t cells that secrete lymphokines

A

sensitized te cells

27
Q

sheep RBC receptor

A

CD2

28
Q

part of t cell Ag- receptor complex

A

CD3

29
Q

classical t cell marker

A

CD2

30
Q

receptor of MHC class 2 molecule (Th)

A

CD4

31
Q

receptor of MHC class 2 molecule (Ts and Tc)

A

CD8

32
Q

receptor of IL-2

A

CD25

33
Q

receptor of pro b cell

A

CD19 and CD45

34
Q

receptor for EBV

A

CD2

35
Q

receptor for b cells

A

surface immunoglobulin (SmIg)

36
Q

they help b cell to develop into antibody-producing plasma cells

A

CD4

37
Q

they help CD* cells to become activated cytotoxic tcells

A

CD4

38
Q

they help macrophages effect delayed hypersensitivity

A

CD4

39
Q

help activate cytotoxic t cells

A

Th 1

40
Q

perform the B cell helper function

A

Th2

41
Q

precursor cell in Ab production

A

b cells

42
Q

primary follicles and red pulp of spleen

A

b cells

43
Q

what are the the b cells development

A

-pro b cells
-pre b cells
-immature b cells
mature b cells
-activated b cells
-plasma cells

44
Q

successful rearrangements of heavy chains

A

pre b cells

45
Q

markers of pro b cells

A

CD19,
CD45R
CD43
CD24

46
Q

synthesis of the heavy chain part of the antibody molecule

-surrogate light chain

A

pre b cells

47
Q

completion of light chain rearrangement commits

A

immature b cells

48
Q

surface proteins of immature b cells

A

CD2
CD40
MHC class 2 molecule

49
Q

IgM and IgD is present on the surface

A

Mature b cells

50
Q

exhibit identiffying marers that include CD25, which is found on both activatedde T and B cells and acts as a receptor fr interleukin-2

A

activated b cells

51
Q

antibody production

A

plasma cells

52
Q

activated by saller amounts of antigen and require less costimulation tha do naive, unactivated t cells

A

memory cells

immunology & serology (3 decks)

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