Congenital Anomoly / Basics Flashcards
What is a choristoma and give an example?
Normal, MATURE tissue at an abnormal location;
- dermoid
- dermolipoma
- ectopic LG
- episcleral osseous choriostoma
What is a hamartoma and give an example?
Exaggerated hypertrophy and hyperplasia (abnl amount) of MATURE tissue at a normal location; cavernous hemangioma
What cells can be found in the wall of blood vessels in some forms of vasculitis?
PMNs
What cells are the tissue-bound equivalent of the bloodborne basophil?
Mast cells
What two cells are characteristic of chronic inflm?
- Monocytes –> migrate from vessel into tissue then called macrophages or histocytes.
- Lymphocytes
What do Langhan cells look like?
Horseshoe arrangement of nuclei on outer edge with clear inner circle
What do Touton giant cells look like?
Have an annulus of nuclei surrounded by a lipid-filled clear zone
What are the 2 syndromes that dermoids are found?
- Goldenhar
2. LINEAR NEVUS SEBACEOUS SYNDROME
Where are dermoid and dermolipomas usually located?
- Dermoid - IT - (contain epidermis and dermis and adnexal structures, NO adipose)
- Dermolipoma - ST - (Softer and more yellow due to adipose tissue in DEEPER layers with NO adnexal structures)
What are 6 syndromes a/w Peter’s anomaly?
- Axenfeld-Reiger
- Congenital rubella
- MLS
- Pfiffer syndrome
- Trisomy 13-15
- Kivilin sydrome
List 5 things that stain PAS +
- Fungi
- Conj goblet cells - mucin
- Cuticular drusen
- Descemets
- Lens capsule and BM
Collodial iron stains for what?
Mucopolysaccride and Macular dystrophy; stains hylauronic acid
Prussian blue stains what?
IRON - stains blue
What are 5 causes of noncaseating granulomas?
- Sarcoid
- TB
- FB reaction
- Fungal infection
- TB infection
Michels fixative is used for what?
immunoflourescence specimens
