Conference #2 Flashcards
2 cardinal findings of achalaisa on manometry?
- LES does not relax
- no peristalsis
which is more sensitive for detecting pancreatic tumor: EUS or CT?
EUS
Sx that suggest dysphagia is due to motility problems?
that suggest mechanical problems?
Motility: dysphagia to liquids and solids, and temp related
Mechanical: progression from solid dysp to liquid dysp
Treatment options for dysphagia due to achalasia?
Ca channel blockers
pneumatic dilation
surgical myotomy
botox
pancreatic cancer: what will be the presentation?
pain, wt loss, jaundice.
prurutis, acholic stools, dark urine
head of the panc: jaundice, steatorrhea, wt loss
body/tail of the panc: pain, wt loss.
panc carcinoma: lab tests will show what pattern?
classic obstructive liver pattern: elevated alk phos, elevated GGT
bottom line: how is the dx of panc cancer made?
radiologically, histologically
EUS more sensitive in detecting pancreatic tumors
acute cholecystitis: what will be lab findings?
elevated bili, AST, ALT
choledocholithiasis - lab findings?
elevated bili, Alk Phos, GGT
ascending cholangitis: labs?
elevated bili, alk phos, GGT, AST, ALT
(everything!)
Best imaging for gallstones?
Abdominal US
best for dx of choledocholithiasis?
ERCP
Risk: 5% pancreatitis!
sx of gastropareisis?
n/v, early satiety, epigastric pain, anorexia, wt loss, GERD, bloating
patho-phys of gastropareisis?
complications of gastroparesis?
-Bezoar formation
GERD
cholecystectomy
metabolic issues
Mallory-Weiss tear
TPN/JTube requirement
what is the sequence for CRC physiology?
most sporadic CR cancers arise from a mutation in what gene?
sequence is polyp–> cancer
APC (adenomatous poluposis coli) gene
accumulation of genetic mutatoins over time, with growth to invasive cancer
Progression: APC, KRAS, Sm16, p53
