Conclusion

Question 1

The precise mechanism underlying acute O2 sensing by glomus cells of CB is yet to be fully understood

Answer 1

with each of the proposed theories facing critique from the field

Question 2

Although the discussed processes can influence glomus cell function

Answer 2

some theories do not seem essential for acute oxygen sensing based on generation of various KO models for genes encoding relevant enzymes/receptors

CB normal response to hypoxia

Question 3

compensation for KO can occur

Answer 3

and in a system like the CB, where one system fails there appears to be an alternative O2 sensing mechanism to step in (Rakoczy, 2017)

Question 4

The contribution of various oxygen sensitive K+ channel subtypes on glomus cell membranes

Answer 4

TASK
Calcium-dependent BKca

suggest that different channels may be linked to different o2 sensors (Kemp)

Question 5

It could also be said that because breathing is such an important phys mechanism

Answer 5

It may be synergistic activity at play to maintain homeostasis

Question 6

Novel hypotheses are continuously being examined

Answer 6

with further ideas still to come

Question 7

It is up to us therefore as future researchers

Answer 7

to further analyse and criticise these theories using critical thinking to come up with effective theories and experiments and indeed someday the precise mechanism of acute oxygen sensing by the CB will be discovered

Question 8

Future directions therefore include

Answer 8

investigation into the potential epigenetic mechanism underlying the CB response to hypoxia such as DNA hypermethylation

Question 9

Systemic and environmental factors may have an influence on the

Answer 9

acute oxygen sensing capacity of the carotid body between individuals (Prabhakar, 2013)