AMPK Theory

Question 1

Increased AMPK activity

Answer 1

(Evans and Peers, 2004)

Question 2

The mitochondria uses oxygen to

Answer 2

produce ATP from AMP

Question 3

In periods of hypoxia

Answer 3

decreased ATP synthesis
increased AMP concentration
AMPK activation

Question 4

Elevated AMPK activation

Answer 4

increased phosphorylation of energy-sensing enzyme

Question 5

pAMPK proposed to inhibit

Answer 5

K+ channels on the glomus cell membrane

Question 6

strengths of theory

Answer 6

ability of pharmacological AMPK activation to mimic effects of hypoxia while AMPK antagonism reversed hypoxic effects

Question 7

Phosphorylation of K+ channels by AMPK suggests a potential mechanism for oxygen sensing however

Answer 7

some researchers are not so convinced

Question 8

While AMPK clearly plays a role in generation of acute hyperventilatory response in KO mice

Answer 8

its role in CB oxygen sensitivity not definitive in research conducted