ROS Theory

Question 1

Fernandes agueres and colleagues

Answer 1

propose a specialised-succinate dependent metabolism of glomus cells suggesting an important role of MCI in oxygen sensing

Question 2

Based on studies in MCI gene, Ndufs2-KO mice

Answer 2

the group hypothesised an increase in ROS alongside reduced pyridine nucleotide levels, as a result of hypoxic MCI inhibition, alters the redox status of K+ channels leading to channel closure

Question 3

The role of oxidative stress in O2 sensing is controversial

Answer 3

however transcriptome analysis of CB cells suggest a unique oxygen sensitivity of CB mitochondria compared to oxygen-insensitive cells (Gao, 2017)

Question 4

Proposing idea that responsiveness of chemoreceptor cells depends on…

Answer 4

‘signature metabolic profile’ (Gao, 2017)

Question 5

FM, the sensitivity of glomus cell mitochondria to changes in O2 tension

Answer 5

has been linked to HIF-2a-dependent expression of atypical mitochondrial subunits suggesting a role of genetic variability in CB response to acute hypoxia (moreno-dominguez, 2020)