Concentration, time and dose

Question 1

What are the main features of a dose-time effect curve?

Answer 1

Tmax, AUC,Cmax, Slope (absorption and elimination)

Question 2

How can a steady state be achieved?

Answer 2

A steady infusion is administered

Question 3

What is phenytoin?

Answer 3

an emergency anti-epileptic drug used to stop epileptic seizures in an emergency
it is efficacious at a concentration of 10-20mg/L

Question 4

how is an infusion rate at steady state calculated?

Answer 4

concentration x CL

Question 5

what is steady state?

Answer 5

where administration and elimination of a drug are in equilibrium

Question 6

What is a loading dose?

Answer 6

loading dose is given to achieve therapeutic conc. quickly.

It’s used when elimination is slow or when a therapeutic concentration must be reached quickly i.e. emergencies

Question 7

what is rosuvastatin?

Answer 7

a statin used to lower cholesterol and prevent complications in patients with ischaemic heart disease
tablet given once a day

Question 8

what are the considerations that must be taken account for oral drugs?

Answer 8

usually not an emergency
patients can take medications at home
must consider how the body affects the drug (PK) specifically metabolism

Question 9

what is vancomycin?

Answer 9

an antibiotic with activity against gram positive bacterial infections.
therapeutic success is associated with total drug exposure (AUC)
Given Intravenously