Concentration - Effect curves

Question 1

What is the theoretical relationship between concentration and effect?

Answer 1

linear relationship

Question 2

What line determines the relationship between concentration and effect?

Answer 2

hyperbolic line = non-linear relationship

Question 3

what is the role of the log-transformation (graph)

Answer 3

used to view the data link between the concentration and effect

Question 4

which coefficient theory supports the Emax model?

Answer 4

Hill coefficient theory

Question 5

what is the hill coefficient theory?

Answer 5

Haemoglobin has 4 binding sites for O = as each is filled, the affinity for oxygen of the others increases

Question 6

what happens to the affinity of the drug as more receptors are occupied?

Answer 6

affinity for the drug increases

Question 7

What happens to the number of sites occupied as the concentration increases?

Answer 7

number of sites increases

Question 8

What is the law of mass action?

Answer 8

Chemical principle that proposes that the rate of a chemical reaction is proportional to the product of the concentration of the reactants

Question 9

What is the Emax model?

Answer 9

E= Emax[D]/EC50 + [D]

Model that describes experimental data mathematically