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Parkinson's Disease Drugs > COMT Inhibitors > Flashcards

COMT Inhibitors Flashcards

1
Q

Examples

A

Entacapone

Tolcapone –> Hepatotoxic

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2
Q

MoA

A

Catechol-O-methyltransferase in synaptic cleft
Inhibitor
Prevents breakdown of Levodopa
Reduces variation in plasma Levodopa levels
Increase effect duration

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3
Q

Indications

A

Parkinson’s Disease (Advance)

1st Line late therapy

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4
Q

ADR

A

Similar to levodopa (Confusion, Motor fluctuations)

Hepatotoxicity

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5
Q

Prescribing Advice

A

NO CHEESE REACTION (MAOI)

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Parkinson's Disease Drugs (6 decks)

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