Compounding I Flashcards
usual BUD for powders
180 days
process of reducing the particle size of a powder
comminution
continuous rubbing or grinding of powder
trituration
uses an intervening solvent to dissolve the powder then the dissolved powder is mixed in a mortar or spread on an ointment slab to enhance evaporation of the solvent allowing the powder to recrystallize
pulverization by intervention
reduce particle size by triturating in a mortar or spatulating on an ointment slab with a small amount of liquid solvent in which the solid is not soluble
levigation
nonpreserved aqueous dosage form BUD
14 days, refrigerate
preserved aqueous dosage form BUD
35 days, refrigerate or room temp
oral nonaqueous liquids BUD
90 days, refrigerate or room temp
other nonaqueous dosage form BUD
180 days, refrigerate or room temp
rule of 7s for capsules
convert contents to grains
subtract grains from 7 and round
1000 mg = 15.43 grains
size range of capsules
000-5
what dosage forms need to be shaken
suspensions and emulsions
properties of a suspension
fine, uniform particles, uniform dispersion, slow settling, ease of redispersion
agents to increase liquid density of a suspension
sucrose, glycerin, sorbitol
agents to induce viscosity of a suspension
acacia, methylcellulose
wetting agents/surfactants in suspensions
glycerin, alcohol, propylene glycol
aw (water activity) > 0.6
aqueous
aqueous solutions include
syrups, aromatic waters, mucilages, aqueous acids
nonaqueous solutions include
solvents other than water
elixirs, spirits, tinctures
1 oz = x mL
29.57 mL
mEq =
mg * valence / MW
mOsmol/L =
(wt of substance/MW) * (# of particles) * 1000
oils, petrolatum hydrocarbons, or waxes dispersed in an aqueous phase
O/W emulsions
water or aqueous solutions dispersed in an oleaginous medium
W/O emulsions
