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PDDS > Compounding Exercise No 7 & 8 > Flashcards

Compounding Exercise No 7 & 8 Flashcards

1
Q

Compounding Exercise no. 7 name is:

A

Glycerin Suppositories

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2
Q

Compounding Exercise no. 7 API and chemical formula:

A

API: Glycerin (CH2OH-CHOH-CH2OH )

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3
Q

A trihydric alcohol, water-soluble, clear, almost
colorless, odorless, viscous, hygroscopic liquid
with a high boiling point

A

API: Glycerin (CH2OH-CHOH-CH2OH )

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4
Q

Glycerin (CH2OH-CHOH-CH2OH ) use:

A

Laxative

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5
Q

Compounding Exercise no. 7 excipients and chemical name and formula, use:

A

Excipient: Stearic acid - n- octadecanoic acid (C18H36O2) used as solidifying agent
Sodium carbonate – stiffening agent

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6
Q

Compounding Exercise no. 7 Raw materials and standard formula:

A

Glycerin 80 g
Monohydrate Na2CO3 2 g
Stearic acid 8 g
Purified water 10 ml
To make 100 g

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7
Q

Compounding Exercise no. 7
Dosage form:
Method use:

A

Suppositories
Fusion Method

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8
Q

Compounding Exercise no. 7
DULCR:

A

Description: bullet-shaped, white insert
Use/s: rectal suppositories as laxative for mild to moderate
constipation
Label: Red
Container: Aluminum foil packed in Ziploc bags
Remarks: Patients should not use laxative products longer than 1
week unless directed by a physician. Store in temperature not
exceeding 8 °C. Keep out of reach of children.

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9
Q

Too much use of laxative may cause?

A

Diarrhea

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10
Q

Glycerol kinase deficiency -

A

hyperglycerolemia

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11
Q

medicated, solid bodies of various sizes and shapes suitable
for introduction into body cavities.

A

Suppositories

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12
Q

Suppositories
- medicated, solid bodies of various sizes and shapes suitable
for introduction into body cavities. The medicament is
incorporated into a base such as ___________which melts at
body temperature, or into one such as _____________n or
_____________ which slowly dissolves in the mucous
secretions

A

Cocoa butter, Glycerinated gelatin, PEG

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13
Q

Common types of suppositories and their weight:

A

Rectal – 2 g and 1g
Vaginal – 3 to 5 g
Urethral -4 g and 2 g

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14
Q

Synonym of the said suppositories:

A

Rectal suppositories
Pessaries
Bougies

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15
Q

Length of the said suppositories:

A

32 mm (cylindrical on one or both ends)

M- 140 mm; f- 70 MM

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16
Q

Shapes of the said suppositories:

A

Bullet-shaped, cylindrical, little finger
Globular, oviform, cone-shaped
Slender pencil-like shape

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17
Q

Examples of the said suppositories:

A

Bisacodyl
Policresulen (Albothyl)
Alprostadil microsuppository

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18
Q

tx of gynecological infection

A

Policresulen

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19
Q

for erectile dysfunction

A

Alprostadil microsuppository

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20
Q

Compounding Exercise no. 7
Bases:

A

Oleaginous (fatty) bases
Water soluble or miscible bases
Miscellaneous Bases

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21
Q

Oleginous bases with their distinctions:

A
  1. Cocoa butter
    - polymorphic base- ability to exist in different crystalline forms
    - Gamma- 18 degress C
    - Alpha- 22 degrees celsius
    - Beta prime - 28 degrees celsius
    - Beta polymorph- 34.5 degrees celsius
  2. Wecobee- coconut oil
  3. Witepsol - lauric acid
  4. Fattibase- triglycerides of palm, palm kernel, & coconut oil
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22
Q
  • most common & a good base for rectal supp.
A

Cocoa butter

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23
Q
  • self-emulsifying glyceral monestearic and polyoxydyl stearic
A

Fattibase

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24
Q

Water soluble or miscible bases:

A

Glycerinated gelatin
Polyethylene glycol bases

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25
Q

common for vaginal suppositories

can be for rectal and urethral

A

Glycerinated gelatin

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26
Q

Polyethylene bases
- polymer of

A

oxide and water

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27
Q

do not melt at body temp. but
dissolve in bodies fluid

A

Polyethylene glycol bases

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28
Q

should contain at least 20% H2O to avoid
from mucous membrane

A

Polyethylene glycol bases

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29
Q

Miscellaneous bases and distinctions:

A

Polyoxyl-40 stearate
- mix. monostearate and distearate esters of mixed polyoxyl ethylenediols and free glycols
- 39-45 degrees celsius

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30
Q
  • preformed emulsion (w/o); ability cooled water and aq. soln
A

Miscellaneous base

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31
Q

melting of Polyoxyl-40-stearate?

A

39-45 degrees celsius

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32
Q

bases should be:

  • ____________, ________, inert, _____
    with medicaments, and easily formed by
    _____ or molding
  • dissolve or disintegrate in the presence of
    _______ or ___________________
    to allow for the release of the medication.
A

non-toxic, nonirritating, compatible, compression

mucous secretions, melt at body temp.

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33
Q

Compounding Exercise no. 7

Methods of Preparation:

A

Hand rolling
Compression
Fusion

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34
Q

It has the advantage of avoiding the
necessity of heating the cocoa butter

oldest and simplest

A

Hand rolling

35
Q
  • Mixture is forced into a special compression mold; Useful for heat
    labile drugs
A

Compression

36
Q

Melted mixture (drug and base) are
poured into mold using mineral oil as
lubricant

A

Fusion method

37
Q

PACKAGING
* Glycerin suppositories and glycerinated gelatin
suppositories
* Cocoa butter suppositories
* Suppositories containing photosensitive drugs

A
  • tightly closed containers
  • individually wrapper or compartment boxes
  • individually wrapped in opaque materials (alum foil)
38
Q

STORAGE
❖ glycerinated gelatin suppositories
❖ Cocoa butter suppositories
❖ PEG suppositories

A
  • controlled room temp. - 20-25
  • below 30, refrigerator- 2-8
  • room temp.
39
Q

increase humidity:

A

absorb moisture; spongy texture

40
Q

increase dryness:

A

lose moisture. brittle

41
Q

Compounding exercise no. 7

Determination of amount of BASE to be used

A
  • (a) dosage replacement factor
  • (b) density factor
  • (c) occupied volume methods
42
Q

→A portion of the suppository base is melted, poured
into the suppository mold and allowed to congeal.
The suppositories are removed from the mold, and
the total weight of the suppositories is determined.

A

Determine the weight of the blank suppository
(Mold Calibration)

43
Q

Compounding Exercise no. 8A:
API and use:

A

API: Calamine is Zinc oxide and 0.5% Fe2o3 as
protectant, astringent

Glycerin as humectant

44
Q

Compounding Exercise no. 8A:
Raw materials and standard formula:

A

Calamine 80 g
Zinc oxide 80 g
Glycerin 20 mL
Bentonite magma 250 mL
Calcium Hydroxide
Solution, q.s. ad. 1000 mL

45
Q

Compounding Exercise no. 8A:
name is:

A

Rx1 – Calamine Lotion

46
Q

Compounding Exercise no. 8A:
Excipients and use:

A

Excipients: Bentonite magma as suspending agent

Calcium hydroxide as vehicle,
astringent

47
Q

Compounding exercise no. 8A:
Dosage form:
Method use:

A

Suspension
Dispersion Method

48
Q

Compounding exercise no. 8A:
DULCRB:

A

Description: Creamy pink suspension
Use/s: Anti-pruritic
Label: Red with shake well instruction
Container: wide mouth amber bottle
Remarks: Keep in a cool dry place away at
room temperature. Avoid freezing
Beyond use date: 14 days

49
Q

are aqueous liquid or
sometimes alcoholic preparation containing
insoluble materials in the form of suspension
or emulsion intended for external application
without rubbing.

50
Q

an o/w emulsion with a high water content
to give the preparation a liquid consistency
can be considered a

51
Q

2 types of lotions and their use:

A

Medicated; exert effects/ calamine lotion

Cosmetic; OTC, for hydration and moisturization

52
Q

contain one or more active
ingredients and a suitable vehicle and are used
for the treatment of skin diseases, or as an
antiseptics, anti-pruritics, antibacterial.

A

Medicated lotions

53
Q

Medicated lotions contain one or more active
ingredients and a suitable vehicle and are used
for the treatment of skin diseases, or as an:

A

antiseptics, anti-pruritics, antibacterial.

54
Q

most lotions are
_____________________ systems; small
amounts of alcohol are added to aid solubilization of the active ingredient(s) and
to hasten evaporation of the solvent from
the skin surface

A

Aqueous or hydroalcoholic

55
Q

Compounding Exercise no. 8A:

Methods of preparations:

A

Dispersion
By chemical interaction
Simple solution

56
Q

Triturating the
ingredients to a smooth paste
(___________) and then cautiously
adding the remaining liquid phase (with
the use of high speed mixers and
homogenizers)

A

Dispersion/ Levigation

57
Q

Dispersion example:

A

Calamine lotion

58
Q

preferred electronic mixers for suspensions and semisolids

59
Q
  • Double decomposition method (AB+CD= AC+BD)
A

By Chemical interaction

60
Q

By chemical interaction examples:

A

White lotion
ZnSO4 + Sulfurated potash (K2S3) →ZnS + 2S + K2SO4

61
Q

in which the
active ingredient is a water soluble
substance

A

Simple solution

62
Q

Simple solution example:

A

Dimethisoquin hydrochloride
lotion

63
Q

Stability of Lotion
* ____, ____, ____ can be used in
place of _______________ as
suspending agent

A

CMC- Carboxy methyl cellulose
MCC- Micro crystalline cellulose
HPMC- Hydroxy propyl methyl cellulose
Bentonite magma

64
Q

may be added in
liquid products to aid the API retain
its desirable properties.

A

Stabilizing agents

65
Q

Stabilizing agents may be added in
liquid products to aid the API retain
its desirable properties. This
includes the gelling agents such as :

A

Cellulose, MSS, CMC

66
Q

Compounding exercise no. 8B:
Name is:

A

Camphor and Soap Liniment

67
Q

Compounding exercise no. 8B:
Raw materials and standard formula:

A

Camphor
in small pieces 215 g
Soap, dried and
granulated 60 g
Rosemary oil 10 mL
Alcohol 700 mL
Purified water, q.s. ad. 1L

68
Q

Compounding exercise no. 8B:
API and distinctions:

A

Camphor - terpenoid found in woof of the camphor laurel (Cinnamomum camphora)

Soap- sodium of potassium salt of fatty acids
- thickener and emulsifier

Rosemary oil- stimulate hair growth, reduce pain, scent

69
Q

Compounding exercise no. 8B:
Excipient and use:

A

Alcohol- solvent

70
Q

Compounding exercise no. 8B:
Dosage form:
Method use:

A

Solutions
Simple solution

71
Q

Compounding exercise no. 8B:
DULCR:

A

Description: whitish, opaque liquid with
mentholated odor of camphor
Use/s: Rubefacient, counter irritant
Label: Red label
Container: Clear or Flint bottle
Remarks: Do not apply on broken skin

72
Q

alcoholic or oleaginous solutions or emulsions of
various medicinal substances intended to be rubbed to the skin

73
Q

Liniments are once called?

A

Embrocations

74
Q

vehicles of liniments

A

Fixed oils

75
Q

Liniments uses labels such as:

A

For external use, Shake well

76
Q

Liniments are applied to?

A

Intact skin

77
Q

Compounding exercise no. 8B:
is used for their ff actions:

A

Rubefacient
Counterirritant
Astringent

78
Q

irritation and reddening of
the skin due to increased blood flow

A

Rubefacient

79
Q

produce surface irritation of
the skin resulting to counteracting underlying
pain or discomfort

A

Counterirritant

80
Q

cause contraction of
skin cells and other body tissues.

A

Astringents

81
Q

Common ingredients of Liniments

A

Menthol, Camphor, Methyl salicylate

82
Q

Herbs of liniments:

A

St John’s Wort, Comfrey, Willowbark,
Cayenne, Arnica, Chamomile,
Turpentine oil

83
Q

source of salicylic acid

A

Willowbark

PDDS (6 decks)

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