Compounding Basics

Question 1

Which chapter of the USP addresses non-sterile compounding?

Answer 1

USP 795

Question 2

Which chapter of the USP addresses hazardous drugs?

Answer 2

USP 800

Question 3

Which chapter of the USP addresses sterile compounding?

Answer 3

USP 797

Question 4

What organization is responsible for determining which drugs are hazardous?
A.) ASHP
B.) USP
C.) FDA
D.) National Institute for Occupational Safety and Health
(NIOSH)

Answer 4

D (NIOSH)

Question 5

What key depression medication is on the NIOSH List?
A.) Fluoxetine
B.) Paroxetine
C.) Bupropion
D.) Quetiapine

Answer 5

B (Paroxetine)

Question 6

What key heart failure medication is on the NIOSH List? (2)
A.) Spironolactone
B.) Entresto
C.) Ivabradine
D.) Carvediol

Answer 6

A, C

Spironolactone, Ivabradine

Question 7

Both C-SECs and C-PECs must have ________________ air pressure at all times.

Answer 7

Negative air pressure

Negative pressure is created when the exhaust system pulls air from the room for safe dispersal.

Question 8

How many air changes per hour must occur in a space where non-sterile Has are being compounded? 
A.) 30
B.) 12 
C.) 15
D.) 10

Answer 8

12 ACPH (air changes per hour)

Question 9

How many air changes per hour must occur in a space where sterile drugs are being compounded? 
A.) 30
B.) 12 
C.) 15
D.) 10

Answer 9

30 ACPH

Question 10

What is an alternative for external exhaust for non-sterile HD compounding?

Answer 10

Redundant-HEPA filters

Question 11

What does CAI stand for?

Answer 11

Compounding Aseptic Isolator

Question 12

What is the name of the isolator glove box for HDs?

Answer 12

Compounding Aseptic Containment Isolator (CACI)

Question 13

What should be used in the disinfection step of sanitization?

Answer 13

Sterile 70% IPA

Question 14

What may be used in the deactivation/decontamination step of sanitization? (2)

Answer 14

2% Bleach

Peroxide

Question 15

How often is the ceiling of the compounding area cleaned?

Answer 15

Monthly

Question 16

How should a PEC be cleaned? (2)

Answer 16

Top to Bottom

Back to Front

Question 17

What components of the compounding area are cleaned weekly? (5)

Answer 17

Walls
Windows
Shelving
Bins
Chairs

Question 18

What are examples of germicidal detergents used for cleaning of HDs? (3)

Answer 18

Quat
Ammonium
Phenolics

Question 19

True or False: A brush may be used to clean up broken glass and powder if an HD spill occurs.

Answer 19

False

Question 20

What color waste bin should be used to discard of HD waste following a spill?

Answer 20

Black

Question 21

What color container is used to discard trace antineoplastic waste?

Answer 21

Yellow

Question 22

How often should gloves be changed when compounding HDs?

Answer 22

30 mins

Question 23

How often should a chemotherapy gown be changed when compounding HDs?

Answer 23

Every 2-3 hours

Question 24

In which room does the hand washing and garbing occur?

Answer 24

Anteroom