Allergies

Question 1

A REMS program is required for the use of which of the following drugs? 
A.) acyclovir 
B.) nortriptyline
C.) isotretinoin
D.) clozapine

Answer 1

Clozapine is associated with severe neutropenia (absolute neutrophil count (ANC) less than 500/μL), which can lead to serious and fatal infections. A REMS is a strategy to manage known or potential risks associated with a drug or group of drugs, and is required by the Food and Drug Administration (FDA) for clozapine to ensure that the benefits of the drug outweigh the risk of severe neutropenia.

Question 2

An iPLEDGE program is required with which of the following drugs?
A.) clozapine
B.) isotretinoin
C.) lamotrigine
D.) phenytoin

Answer 2

B

A monthly pregnancy test is required prior to refilling isotretinoin due to risk of fetal toxicity.

Question 3

What two classes cause the most drug allergies?
A.) Opioids 
B.) Penicillins 
C.) Sulfonamides 
D.) NSAIDs

Answer 3

B, C

Penicillin and sulfonamides

Question 4

Clevidipine (Cleviprex) has how many kcal/ml?

Answer 4

2 kcal/ml

Question 5

Propofol (Diprivan) has how many kcal/ml?

Answer 5

1.1 kcal/ml

Question 6

Where should you report adverse events, side effects, and allergies of drugs?

Answer 6

FDA MedWatch Program, which is called FDA’s Adverse Event Reporting System (FAERS).

Question 7

Where should you report adverse events, side effects, and allergies for vaccines?

Answer 7

Vaccine Adverse Event Reporting System (VAERS)

Question 8

What tool is used to determine if an ADR is related to a drug?

Answer 8

Naranjo Scale

higher score= higher probability it is related to a drug

Question 9

Key questions to ask pts in regard to reported allergies? (4)

Answer 9

1. ) What kind of reaction occurred?
2. ) When did it occur? About how old were you?
3. ) Can you use drugs in a similar class?
4. ) Do you have any food and latex allergies?