Compostion Of Skin Flashcards
1
Q
To enter G1 a cell must
A
- Sense adhesion
- Ample nutrients
- GF
2
Q
What does an increase of cyclin D lead to
A
Proliferation; CDK2, CDK4
3
Q
What does CDK4/6 code for
A
CDK1/2, cyclin A, B, E
4
Q
What happens when BAD is not phosphorylated
A
Leads to apoptosis
5
Q
What inactivates BAD
A
AKT (from PIP3)
6
Q
What are the end products of the RAS MAP pathway
A
- Myc and fos
2. Jun and fos
7
Q
What degrades B-catenin
A
APC
8
Q
What does B catenin do
A
Produce high myc and cyclin D
9
Q
How does p53 result in the stopping the cell cycle
A
p53, p21, cyclin inhibitor
10
Q
What is the purpose of MDM
A
To signal p53 has saved the day
11
Q
What does BAX indicate
A
Apoptosis
12
Q
What molecule keeps RB bound to E2F
A
P21
