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Biochemistry > Complex Lipid > Flashcards

Complex Lipid Flashcards

1
Q

The only phosphoglyceride that is antigenic

A

Cardiolipin

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2
Q

Cardiolipin is found in

A

Inner mitochondrial membrane

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3
Q

3 major classes of plasmologers

A

Phosphotidal choline → heart
phosphotidal ethandomine → myelin
Phosphotidas serine

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4
Q

G lycerophospho lipid synthesis

A

CDP diacylglycerol + alcohol
CDP-alcohol + diacylglycerol

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5
Q
  • —… can provide arachidonate for
    eicosanoid synthesis
A

Phosphatidic acid

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6
Q

Bee and snake venoms are rich sources of

A

Phospholipase A2

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7
Q

Long chain FA+ amino group of sphingosine

A

Ceramide

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8
Q

Sphingonyelinase deficiency

A

Neumann - pick disease

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9
Q

Neutral glycosphingolipids

A

Globoside r cerebreside

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10
Q

Acidic Glycosphingolipids

A

Gangliosides
Sulfatides

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11
Q

Accumulation of gangliosides ❖Rapid, progressive and fatal
neurodegeneration ❖Blindness
❖Cherry red macula ❖Muscular weakness ❖Seizures

A

Tay Sachs disease

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12
Q

Accumulation of globosides
Fabry disease
❖Reddish-purple skin rash
❖Kidney and heart failure
❖Burning pain in lower extremities (peripheral neuropathy)

A

Fabry disease

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13
Q

Phosphatidic acid is composed of

A

-glycerol + phosphate + 2 fatty acyl chains

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14
Q

Plasminogens are…. Linked instead of….. Linked

A

Ether ester

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15
Q

Glycerophospholipid synthesis

A

– CDP-diacylglycerol + alcohol or
– CDP-alcohol + diacylglycerol

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16
Q

DPPC(dipalmitoyl phosphatidyl choline)

A

is the major component of lung surfactant

17
Q

Accumulation of gangliosides

A

Tay sachs

18
Q

Accumulation of glucocerebrosides

A

Gaucher disease

19
Q

Accumulation of globosides

A

Fabry disease

Biochemistry (9 decks)

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