Adipose Tissue Biochemistry Flashcards
2 types of adipose tissue ?
White adipose tissue
Brown adipose tissue
…………. restricts lipolysis under basal conditions
Peilipin 1
↑ TNF -alpha and IL-6
Loss of perilipin 1 → obesity
Primary function of bat
Non shivering thermogenesis with UCP -1
Beige adipocytes derived from —-
WAT
cell signaling proteins secreted by adipose tissue
Adipokines
Adipocytokines
Adipokines
Leptin
Adiponectin
TNF -a
Il-6
Plasminogen activator inhibitor (pai-1)
MCP -I
RBP -4
Visfatin
In obese resistin is
↑
Adipsin levels are low in patients with —-
Anorexia nervosa
Cause of insulin resistance
TNF a
IL6
Nefa
Resistin
Improve insulin resistance
Leptin
Adiponectin
………….metabolic syndrome, vascular thromboembolic events, and acute coronary syndrome.
PAI1
innate immunity
Visfatin
Leptin ………… body weight
↓
Wat stores
Triglycerides
Increases nitric oxide (NO)
production in endothelial cells.
Apelin
Serum PAI-1 levels decrease with
weight loss, and metformin therapy.
PAI-1 is increased in
Metabolic Syndrome, vascular thromboembolic events, and
acute coronary syndrome.
Its major function is related to energy metabolism and innate immunity and it
is regarded as a pro-inflammatory adipocytokine.
Visfatin
It induces leukocytes and stimulate production of TNF-α and IL-6.
Visfatin