Complex inheritance of common multifactorial disorders Flashcards
how does inheritance usually occur
due to gene-gene and gene-environment interactions
run in family refers to
cluster among relatives of affected individuals more frequently than in general pop.
allele sharing among relatives refers to what idea
the more closely related two family members are, the more alleles they share, inherited from common ancestors ex. monozygotic twins
what is parent-child pairs (trios)
child has 50% of alleles in common with each parent at every locus
siblings share what percentage of their alleles
have 50% of their alleles in common with other siblings
The larger the relative risk ratio is…
the greater the familial aggregation
If relative risk ratio is less than 1…
relative less likely to develop disease than any individual in population
if relative risk ratio is greater than 1…
relative more likely to develop disease
Monozygotic twins share what percent of alleles
100%
Dizygotic twins shares what percent of alleles
50%
What is concordance
twins have the same disease
genetic variation contributes to diseases with
complex inheritance
in familial aggregation, relatives of affected individual are…
more likely to have diease predisposing alleles (mutated allele or disease risk allele)
lack of penetrance
pairs of relatives who share disease-predisposing genotypes at relevant loci may still be discordant
what is an example of common multifactorial disease with genetic contribution
neuropsychiatric disorders
ex. bipolar disease, schizophrenia
