Complex Disorders

Question 1

Large GWAS sample sizes must be used for schizophrenia combining sets of meta analyses
Y - significance if more than 10-8
X- SNP locus (chromosome)

Answer 1

If GWAS is statistically significant variants still only makes a small contribution

Question 2

CNVs have a role in disease in complex disorders

Possible structural rearrangements deletion duplication 0,1,3

Answer 2

CNV facts- 
5-25% genome CNVs 
Most harmless polymorphisms
Some contribute to disease
CNVs often famlies paradox 
Stronger effects than SNPs but still not cause, just INCREASED RISK
Useful in schizophrenia autism

Question 3

Chromosome abnormalities contribute largely to autism
Some CNVs identified in multiple individuals
16p CNVs in autism
Most down to unknown causes

Answer 3

H

Question 4

Twin studies - genetic contribution not environment)

Epidemiology useful

Answer 4

She

Question 5

GWAS genome wide association study

Answer 5

If SNPs in genes are associated with disease

Manhattan plots