Complete Deck Part 1 Flashcards
When should Intercourse be avoided during Pregnancy?
Cervical dilation, placenta previa, premature labor, vaginal bleeding, ruptured membranes, genital herpes
What is Type 2 RTA?
Proximal RTA: bad Carbonic Anhydrase, lost all HCO3-
What is Heavy Chain Disease?
IgA and Multiple Myeloma of the GI tract
What is Nihilism?
Feeling of “life is meaningless”
What is Forward Typing?
Uses Antibodies to detect Antigens
What is associated with Vibrio Vulnificus?
Raw Oyster - common in workers shucking the oysters, cellulitis in swimmer’s cuts
What is the MOA of Propranolol, Timolol?
B1 and B2 Blockers
What is Hand-Foot-Mouth Disease?
Mouth ulcersWill not eat or drinkPalm and sole rash caused by Coxsackie A
What are the 2 kinds of partial seizures?
Simple (aware), complex (not aware)
What is an Omphalocele?
Intestines protrude out of the umbilicus covered by peritoneum
What is Clanging?
Words that sound alike
What is exudate?
Effusion of mostly proteinToo much protein: Will have —Purulent (from Bacteria),Hemorrhagic (from trauma, CA, PE)Fibrinous (from collagen vascular disease), Granulomatous (non-bacterial)
What are the Mimetic drugs?
Pramlintide
What is Lewy Body Dementia?
Stiff with visual hallucinations
What type of problem is there if serum Ca2+ and Serum PO4- change in same directions?
This is a secondary problem
What is the Pool Test?
Fluid in the vagina
What are the indications for Odansetron?
Control vomiting in patients undergoing chemo therapy and postoperatively
What is Kd?
Concentration of drug that binds 50% of receptors
What is associated with H. Aegyptius?
Swollen eyeball with pus
What is Overflow Incontinence?
Cannot completely empty bladder
How does Gonorrhea present?
Palmar pustules, arthritis/joint pain, urethral discomfor
What makes Achalasia unique?
Decreased Peristalsis and increased LES pressure
What is the MOA of Pseudoephedrine, phenylephrine?
Sympathomimetic alpha-agonistsnon-prescription nasal decongestants
Where does DHT come from?
Testicles at puberty
What is Intraductal Papilloma?
Bleeding from the nippleMost common Breast CA
How does temporal arteritis present?
Pain with chewing, blind in one eye
What diseases have PIE syndrome?
Aspergillus, Loeffler’s, Churg-Strauss
What is associated with Fusobacterium?
Painful mouth ulcers, gum pus, Vincent’s angina
What is the MOA of ACE inhibitors?
Inhibits conversion of Ang I to Ang II, decreases Ang II
What is Central (neurogenic) diabetes insipidus?
Brain not making or producing enough ADH
What is Arnold-Chiari?
Foramen Magnum obstruction
What is 1st-order kinetics?
Constant drug percentage metabolism over time depends on drug concentration (rate of elimination is directly proportional to drug concentration)
What does Vit B2 do?
FAD cofactor
Clues for atypical pneumonia?
Atypical pneumonia: prolonged illness, low fever, usually >40 y/oX-ray: diffuse, H. Influenza, Mycoplasma, Chlamydia
What does giving DDAVP during the Water deprivation tests tell you?
> 50% increase (central complete DI),10-50% increase (central partial DI),<10% (psychogenic polydipsia),no change (nephrogenic DI)
What will you see with Alpha Thalassemia?
Seen in African Americans and Asian Americans (Chromosome 16- deletion)
What are the simple Gram Negative Bugs?
They lack Lipopolysaccharides,”Simple HE”H - H. InfluenzaE - E. Coli
What is a Neutrophil?
The Phagocyte (it has Antimicrobials, most abundant)
What is the MOA of Glucocorticoids?
Decrease production of Leukotrienes and prostaglandins by inhibiting phospholipase A2 and expression of COX-2
What is Transference?
Patient views doctor as parent
Where is the most common site of a Clavicle fracture due to birth?
Middle third of the Clavicle
What are the indications for Niacin?
Decrease LDL and TriglyceridesStrong increase HDL
What is Perseveration?
Keeps repeating the same words
What does the parathyroid cells secrete?
PTH
What is associated with Actinomyces?
Face Fistulas, Sulfur Granules
What is a Rolling Hiatal Hernia?
Bowel Protruded through a defect in the Diaphragm. This can strangulate the bowel and can cause Atelectasis
What is Mesenteric Ischemia?
Abdominal pain of of proportion to physical exam
What is the MOA of Diazoxide?
K+ channel opener, hyperpolarizes and relaxes smooth muscle
What is Primary Sclerosing Cholangitis?
Anti-smooth muscle antibody (20-50%), bile ducts are scarred from inflammation, there is beading and onion skinning, it’s associated with UC and P-ANCA (80%)
What does the viral load tell you?
Progression of HIV
Which enlarged lymph nodes are most likely malignant?
Supraclavicular, Epitrochlear (above the elbow), inguinal
What is Velamentous Cord Insertion?
Fetal vessels insert between chorion and amnion
What is Common Variable Immuno. Def?
Young adults with B cells that do not work
What are the Indications for Oxytocin?
Induces labor and Controls uterine hemorrhage
What does Mg2+ do?
PTH and kinase cofactor
What are the risk factors for Lung CA?
Smoking, Radon, second hand smoke, pneumoconiosis (except Anthracosis)
What is the Adverse Effect for first generation Sulfonylureas?
Disulfiram like effects
What is Multiple Myeloma?
Multiple osteolytic lesionsIncreased IgG and kappa light chainsRouleaux formation seen on slide
Clues for Typical pneumonia?
Typical pneumonia: short illness, high fever, usually >40 y/o, X-ray: one lobe, Streptococcus Pneumonia
What is Polycythemia Vera?
Hematocrit (Hct) >60% Decreased EPO, Budd-ChiariPruritis after bathing
What is the MOA of Mimetics?
Decreases Glucagon
What is Ascending Cholangitis?
Common bile duct infection due to stones
What does Growth Hormone (GH) do?
Stimulates growth, sends Somatomedin to growth plates, Gluconeogenesis by proteolysis
What is Anderson’s?
Branching enzyme deficiency, long chains of glycogen
What is the Sympathetic System?
Fight -or- Flight, speeds stuff up
What is a Double Footling Breech?
Two feet sticking outside the cervical OS
What vessel has the thickest layer of smooth muscle?
Aorta
What is Competitive Inhibition?
Fights for active site, no change in Vmax, potency decreases
What does blood type O tell you?
They have no antigens (Universal donor)
What does high WBC and B Cells tell you?
Bacterial infection
What are the Rapidly Dividing Cells of the Energy State?
Skin: dryNails: BrittleHair: AlopeciaLow Bone Marrow: SuppressedVasculature: Endothelium breaks downLungs: Infection / SOBKidney: PCT effecfted firstGI: N/V/DBladder: Decreased toneSperm: DecreasedGerm Cells: Predisposed to cancerBreasts: AtrophicEndometrium: Amenorrhea
What diseases are cause by the Ixodes Ticks?
Lyme Disease - bull’s eye lesionBabesiosis - Hemolytic AnemiaEhrlichiosis - puncture near eye
What does a Dehydrogenase do?
Catalyzes Oxidation-Reduction reactions (gaining or losing an electron)
What is Unconjugated Bilirubin?
Fat soluble and indirect Bilirubin
What is a transition?
Changes one purine to another purine
What is Crigler-Najjar Type I?
Unconjugated bilirubin buildupNewborn or infantsNo UDP-GTPhenobarbital yields no change
What organ has the highest AVO2 difference after excercise?
Muscle
What are the bugs that cause gastroenteritis within 8 hours of eating the preformed toxin?
Staph Aureus (potato salad)Clostridium Perfringens (holiday turkey/ham)Bacillus Cereus (fried rice syndrome)
What are the most common places to metastasize to the brain?
From the lung, breast, and skin, present at the White-Grey Junction
What is Polyhydramnios?
Too much amniotic fluid (baby can’t swallow)
What is the function of GnRH?
Stimulates release of LH & FSH
What are the risk factors for Esophageal / Gastric CA?
Smoking, alcohol and nitrates
What is Slipped Capital Femoral Epiphysis?
Gradual or acute separation of the proximal femoral growth plate with femur head slipping off femoral neck and rotating into inferior-posterior position. Most common during puberty and more in overweight individuals, present with a limp and pain recurring often to the kneeLimited hip internal rotation and outward rotation of lump with hip flexionx-ray: epiphyseal displacement
FEV1/FVC in Restrictive lung disease
Normal or elevated
What has Waxy Casts?
Chronic Renal Failure
What are the only Gram-negative diplococci?
Neisseriamoraxella
How does a VIPoma present?
Watery diarrhea
What are the indications for the Class IB antiarrhythmic?
Decrease AP duration, acute ventricular Arrhythmias, local anesthesia
What defines Diarrhea?
> 200 grams of stool per day
What defines constipation?
Less than 3 bowel movements per week
What defines ALL?
0-15 year old males, bone pain, + PAS stain and +TdT. CALLA antigen positiveT (12;21)
What is the MOA of Class IB antiarrhythmic?
Na+ channel blocker
What is a Duodenal Ulcer?
Pain 20-30 minutes after eating, relieved with food, caused by H. Pylori infection 80-90% of the time and weight gain
What is a Female Pseudohermaphrodite?
XX with LOW 21-OHase and HIGH Testosterone
What are the adverse effects of Acid Resins?
Tastes bad and causes GI discomfortbile decreases absorption of fat soluble vitaminscholesterol gallstones
What is Hurler’s?
Alph-L-Iduronidase deficiencyworse formGargoylismCorneal cloudingaccumulation of Heparin and Dermatan Sulfate
What are the indications for fibrates?
Strong decrease of triglyceridesslight decrease of LDLslight increase in HDL
What are the classifications of MHC-2?
HLA-DP, HLA-DQ, HLA-DR
What is Cori’s?
Debranching, a-1,6 glucosidase enzyme deficiencyshort branches of glycogenmilder form of von Gierke with normal lactate levelslimit-dextrin’s accumulate
How does Choanal Atresia Present?
Baby turns blue with feeding, pinks up when breast of bottle is removed (blocked nasal passages)
What is the job of the Proximal Convoluted Tubule?
Reabsorb Glucose, Amino Acids, Salt, Bicarb. >60-80% Reabsorption occurs here
What is Bronchiectasis?
Bad breath, purulent sputum, and hemoptysis
What electrolytes does the low volume state have?
Increased total Na+ (NET)Decreased serum Na (dilution effect)Decreased serum K+Increased serum pH
In what layers does a pseudo aortic aneurysm occur?
Intima and media layers
Who makes the Syncytiotrophoblast?
Mom and baby production of HCG and HPL
What is Metorrhagia
Bleeding or spotting in btwn periods
How does Spastic Colon present?
Intermittent severe cramps
What is selective IgG2 Deficiency?
Seen in patients with recurrent encapsulated infections
What diseases have respiratory acidosis?
Obstructive lung diseases
What is Prinzmetal’s angina?
Coronary Artery Spasm
What does high WBC and High PMN’s tell you?
Stress demargination. (Stress response - post trauma)
What causes a Cleft Palate?
Maxillary shelves did not fuse
What is Rouleaux formation?
Seen in Multiple Myeloma (Stacked coin look)
What is Neologisms?
New words
What is Nephrotic Kidney Disease?
Lostbasement membrange chargeProteinuria >3.5hypercoagulablelipiduria
What does a Phosphatase do?
Removes Phosphate from substrate
What bug loves the parietal lobe?
Toxoplasma
What bug is associated with Cat Scratch?
Bartonella Henselae
What is Selective IgA Deficiency?
Seen in transfusion, anaphylaxis, and mucus membrane infections
What is the Trough level?
2 hours before next dose (too high - give less often)
What is VHL?
Predisposes individuals to bnign and malignant tumors, AVM in the head, and retina (AD inheritance in Chromosome 3)
What causes a Cleft Lip?
Medial nasal prominence did not fuse
What is the MOA of Reserpine?
Prevents the storage of monoamines in synaptic vesicle
What are the 3 tests used to screen for HIV?
ELISA: Detects IgG Ab to p24 AgWestern Blot: ProteinsPCR: Detects Virus (used in babies)
What is Materninty Blues?
Postpartum crying and irritability
What are the inidications for PPIs?
Peptic ulcer, gastritis, mid-esophageal Reflux and Zollinger-Ellison syndrome
What are the Ca2+ channel blockers?
Verapamil, Diltiazem
What is Conn’s Syndrome?
High Aldosterone (primary tumor), Cpatopril test makes it worse, and increase’s secretin hormone
What color is stool with a Lower GI Bleed?
Bright Red Blood (Hematochezia)
What is Type 5 Hypderlipidemia?
Defective enzyme and receptor (C-II) Elevated VLDL and ChylomicronsAssociated with DM
What is the RBC lifespan when there is a problem?
60-90 days (same time as the shelf life of blood bank units)
What sound radiates to the back?
Pulmonic stenosis
What is the MOA of Prazosin?
Alpha 1-Blocker, vasodilation, decreases TPR
What is Sandhoff’s?
Hexosaminidase A/B deficiency
What is the MOA of Octreotide (Synthetic analog of Somatostatin)?
Decreases release of GH, Gastrin, CCK, Carcinoid, VUP, Glucagon and Insulin
How is Smallpox different from Chickenpox?
Smallpox is on the face, same stage of development and fever
What is Diffusion?
From high to low concentration No ATP
What are the Fibrates?
Gemfibrozil, Clofibrate, Bezafibrate, Fenofibrate
What is Anthracosis?
Coal workers, extensive fibrosis
What is Conduct Disorder?
Younger than 18 y/o with traits of antisocial disorder: aggressive, disregard for authority/rules, no sense of guilt/remorse, harms animals, illegal activity “bite is worse than bark”. Behavioral therapy and antipsychotic
What are the names of the B vitamins?
“The Rich Never Lie about Panning Pyrite Filled Creeks”Vit B1 = ThiamineVit B2 = RiboflavinVit B3 = NiacinVit B4 = Lipoic acidVit B5 = Pantothenic acidVit B6 = PyridoxineVit B7 = BiotinVit B9 = FolateVit B12 = Cobalamin
What 5 bugs cause heart block infections?
“Don’t TeLL Chaga”D- DiphtheriaT- Typhoid Fever (Salmonella Typhi)L- LegionellaL- Lyme DiseaseC- Chagas Disease (Whipple’s)
What is a Complete Abortion?
Cervix is closed, no fetal remnants, check B-HCG level
What is a “Blue Bloater”?
Chronic Bronchitis
What are the Indications for ACE inhibitors?
HTN, CHF, post MI and vasodilation
What is the MOA osmotic Laxatives?
Provide osmotic load to draw water outLactulose treats Hepatic encephalopathy: gut flora degrades it into metabolites (lactic acid and acetic acid) that promote Nitrogen excretion as NH4+
What is the treatment for hypercholesterolemia?
Statins
What are the adverse effects of Minoxidil?
Hypertrichosis and Pericardial Effusion
What are the adverse effects of adenosine?
flushing, hypotension, and chest pain very short acting
What are the Glucocorticoid drugs?
Hydrocortisone, Triamcinolone, Dexamethasone, Prednisone, Beclomethasone
Whatis Pheochromocytoma?
Adrenal medulla tumor in adults, they will have five P’s: Palpitations, Perspiration, Pallor, Pressure (HTN), and Pain (headache)
What is Byssinosis?
Cotton workers, textile workers
What is Chediak Higashi?
Lazy Leukocyte Syndrome(Lysosomes are slow to fuse around bacteria)
What is Korsakoff Psychosis?
Alcoholic Thiamine deficiency. Presents with confusion, Opthalmoplegia, ataxia, memory loss, confabulation and personality changeTx: Vit B1
What type of Kidney Stones have Coffin-Lid Crystals?
Triple Phosphate (Struvite)