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Complete blood count Flashcards

1
Q

What are the tests that are usually included in a CBC?

A

1) White blood count (WBC)
2) Red blood cell count (RBC)
3) Hematocrit (Hct)
4) Hemoglobin (Hb or Hgb)
5) Red blood cell indices
6) Differential WBC count or ‘diff’ and platelet count (possible or ordered seperately

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2
Q

What are the components in a Red blood cell indices test

A

1) Mean corpuscular volume (MCV)
2) Mean corpuscular hemoglobin (MCH)
3) Mean corpuscular hemoglobin concentration (MCHC) -

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3
Q

What is measure in a Mean corpuscular volume (MCV) test?

A

The Average red blood cell size

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4
Q

What is measure in a Mean corpuscular hemoglobin (MCH) test?

A

The amount of hemoglobin per red blood cell

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5
Q

What is measure in a Mean corpuscular hemoglobin concentration (MCHC) test?

A

The amount of hemoglobin relative to the size of the cell or hemoglobin concentration per RBC

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6
Q

What is the primary function of Red blood cells

A

To carry oxygen from the lungs to the body tissues and to transfer CO2 from the tissues to the lungs

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7
Q

Oxygen is transferred via the red blood cell by what?

A

Hemoglobin

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8
Q

How are RBC shaped and what are they shaped that way?

A

They are shaped like biconcave discs to enable the maximum O2 saturation of hemoglobin (the biconcave shape provides more of a surface area for exposure of hemoglobin to dissolved O2.

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9
Q

What is the metric by which RBCs are counted

A

RBC per cubic millimeter of blood

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10
Q

An increase in RBC is called

A

Polycythemia

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11
Q

What are situations in which an increase of RBCs is considered ‘normal’

A

1) High altitudes
2) After strenuous physical training
3) (not normal but…) Smokers have a higher RBC count than non-smokes

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12
Q

What is Polycythemia vera (what causes it)

A

An abnormal increase of RBC in the blood marrow not caused by physiological need (cause unknown)

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13
Q

What is an important consideration for someone with an abnormally high RBC count (why?)

A

Hydration is an important consideration when caring for a patient with a high RBC count. It’s important because a very high RBC mass will slow blood velocity and increase the risk of intravascular clotting

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14
Q

What is the general term for someone with a low RBC count

A

Anemia (can also result from a low hemoglobin count)

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15
Q

What are some causes of a decreased RBC count

A

1) Acute hemorrhage
2) Abnormal destruction of RBC
3) lack of substances needed for RBC production
4) Chemo or radiation sfx

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16
Q

What is a reticulocyte

A

An immature form of erythrocytes (RBCs)

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17
Q

What are is a normal reticulocyte count (in men and women)

A

Men - 0.5% to 1.5% of total # of RBCs

Women - 0.5% to 2.5% of total # of RBCs

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18
Q

What could be some causes of low or high reticulocyte counts

A

Low - cirrhosis, folic acid deficiency, bone marrow failure.

High - Bone marrow is responding to an increased RBC production. Also anemia or recent blood donors

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19
Q

Hematocrit aka…

A

“Hct”, “crit”, or PCV (packed cell volume)

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20
Q

What does Hematocrit determine?

A

the percentage of RBC in plasma.

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21
Q

If RBC and hemoglobin are normal. What would you estimate to be the approximate hematocrit in the blood?

A

Three times the hemoglobin.

For example: If a person’s hematocrit is 30%, he would have a hemoglobin of approx 10gm

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22
Q

What are the critical high and low values of hematocrit

A

Low - under 15% can result in cardiac failure

High - above 60% may result in spontaneous blood clotting

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23
Q

Is the hematocrit level relative to the % of RBC or total volume of blood?

A

RBC %. So if a person looses a good amount of plasma volume, the hematocrit level will go up. Over hydration will result in a lower hematocrit level.

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24
Q

In supplying packed RBC to correct anemia. How much of an increase in hematocrit levels should you expect

A

Hematocrit should rise approx. 3% per each unit transferred

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25
How long does it take for the bone marrow to produce mature RBC
Approx 10 days
26
What is a hematocrit test done frequently for
To determine the extent of significant blood loss after a major hemorrhage
27
Why is testing hematocrit a good way to assess the extent of significant blood loss?
Because after a hemorrhage RBC and plasma are lost in equal proportions, but plasma (volume) is replaced a lot quicker (hours from intestines) than RBC (10 days). So a hematocrit hours after a hemorrhage will show a more accurate picture of the significant of the effect of blood lost.
28
What are the 2 types of hemoglobin subunits
Alpha and beta
29
How much O2 can each gram of hemoglobin carry?
1.34 ml of O2 per gram of hemoglobin
30
What is hemoglobin's role in ECF
Acts as an important pH buffer
31
What contributes to a decreased hemoglobin
1) Blood loss and bone marrow suppression (go hand in hand with a lower RBC count) 2) Also those who have an abnormal type of hemoglobin. 3) Iron deficiency anemia (normal RBC but low hemo)
32
What is another term for iron deficiency anemia
Hypochromic anemia (less than normal color anemia)
33
What contributes to increased levels of hemoglobin
Anything that would contribute to an increased # of RBC circulating in the blood... - polycythemia vera - severe burns - chronic obstructive pulmonary disease - CHF
34
What are the critical low/high values of hemoglobin?
Low: under 5 g/dL may cause heart failure | Hight - over 20g/dl may cause clogging of capillaries due to hemoconcentration
35
How does erythrocyte indices help determine info on different types of anemia
It determines whether the RBC are of normal size or if they have a normal concentration of hemoglobin
36
How is Mean Corpuscular Volume (MCV) determined and what does a low/high reading determine
Determined by hematocrit divided by total RBC count Low = cells are smaller than normal (microcytic) High = cells are larger than normal (macrocytic)
37
What conditions are microcytic RBC seen in
1) Iron deficiency anemia 2) Lead poisoning 3) Thalassemia major and minor (genetic disease)
38
What conditions are macrocytic RBC seen in
1) Pernicious anemia | 2) folic acid deficiency
39
What is it called when the MCV is within normal range
Normocytic
40
What kind of anemia can a person with normocytic anemia have
Anemia from an acute hemorrhage.
41
How is Mean corpuscular hemoglobin (MCH) determined
Weight of hemoglobin = hemoglobin divided by total RBC count x 100
42
How is MCH measured
The weight in of hemoglobin in an average cell is measured in pictograms (pg). MCH is reported in a percentage (hemoglobin in the RBC)
43
What erythrocyte indices determine if RBC are deficient in hemoglobin concentration
an MCHC less than 32% or an MCH under 27%
44
What are the two classifications (groups) of leukocytes
1) Granulocytes - have granules in cytoplasm | 2) Non-granulocytes (agranulocytes)
45
What are two non-granulocytic WBC
Lymphocytes and monocytes
46
What kind of nuclei do lymphocytes and monocytes have
Non-lobular
47
What are three granulocytic WBC
Neutrophils, eosinophils and basophils
48
What kind of nuclei do granulocytes neutrophils, eosinophils and basophils have? (what are they also known as)
Multilobed nuclei (aka polymorphonuclear leukocytes or polys). Nuclei of neutrocytes are also segmented and they can also be called 'segs'.
49
What is the lifespan of a WBC
13-20 days
50
What are immature WBCs released into the peripheral blood called
Bands or stabs
51
Define phagocytosis
Where WBC (leukocytes) surround and destroy foreign organisms
52
What are two measurements of WBC commonly done in a CBC
1) Total # of WBC in a microliter of blood (reported as an absolute # of "X" thousands of WBCs. 2) The percentage of each of the 5 types of WBC
53
What is the test to determine the percentage of the 5 different type of WBC called
A differential or diff. (reported in percentages)
54
What determines Leukocytosis
a WBC above 10,000
55
What is Colony stimulating factor (CSF)
a substance released by WBC in response to an acute infection, trauma or inflammation. It stimulates the bone marrow to increase WBC production
56
What can mask leukocytosis
corticosteroids
57
What is Leukopenia
A low WBC count
58
How is Leukopenia defined
When WBC falls below 4000.
59
What can cause leukopenia
1) Viral infections 2) Bacterial infections 3) Bone marrow disorders
60
What is the role of neutrophils
They are the body's primary defense against bacterial infections and physiologic stress (severe burns or MI)
61
A decreased # of neutrophils is called
Neutropenia
62
What can cause neutropenia
1) Some bacterial infections (the # goes down instead of up) like typhoid fever or brucellosis 2) Many viral diseases 3) Many antineoplastic drugs (that fight cancer) that can produce bone marrow depression
63
What is an important consideration for someone with an abnormally high RBC count? (why?)
Hydration is an important consideration when caring for a patient with a high RBC count. It's important because a very high RBC mass will slow blood velocity and increase the risk of intravascular clotting
64
The oxygen carrying ability of blood is directly proportional to?
... it's hemoglobin concentration (not RBCs because they can have a varying amount of hemoglobin)
65
What is the physical structure of hemoglobin?
A molecure comprised of 4 subunits, each of which contains an iron containing pigment (heme) and a protein (globulin)
66
What is hemoglobin determination used to screen?
1) Anemia (diagnose, its severity and to assist in evaluating the patient's response to anemia therapy
67
How does erythrocyte indices help determine info on different types of anemia?
It determines whether the RBC are of normal size or if they have a normal concentration of hemoglobin
68
What kind of anemia can a person with normocytic anemia have?
Anemia from an acute hemorrhage.
69
What erythrocyte indices determine anemia from acute blood loss?
MCV, MCH, and MCHC normal - Normocytic and normochromic anemia
70
What erythrocyte indices determine anemia from iron deficiency ?
MCV, MCH, and MCHC decreased - microcytic and hypochronic anemia
71
What erythrocyte indices determine pernicious anemia?
Increased MCV, variable MCH, and MCHC. Macrocytic anemia caused by vitamin B12 deficiency and folic acid deficiency
72
What are the two classifications (groups) of leukocytes?
1) Granulocytes - have granules in cytoplasm | 2) Non-granulocytes (agranulocytes)
73
What are two non-granulocytic WBC?
Lymphocytes and monocytes
74
What is the test to determine the percentage of the 5 different type of WBC called?
A differential or diff. (reported in percentages)
75
Name the 5 types of Leukocytosis.
1) Neutrophilia 2) Lymphocytosis 3) Eosinophilia 4) Monocytosis 5) Basophilia
76
What is Colony stimulating factor (CSF)?
a substance released by WBC in response to an acute infection, trauma or inflammation. It stimulates the bone marrow to increase WBC production
77
What is blood determination is a sign of infection?
Leukocytosis
78
What can cause leukopenia?
1) Viral infections 2) Bacterial infections 3) Bone marrow disorders
79
What are Leukocytes critical low/high values?
Low: 30,000 indicates massive infection or serious disease like leukemia
80
What does 'shift to the left' mean in a WBC count?
An increased number of less mature neutrophils (bands or stabs) in the blood (indicating an infection is in progress)
81
What are eosinophils associated with?
Antigen-antibody reactions (allergic reactions like hay fever, asthma and drug hypersensitivity
82
What might cause a decrease in eosinophils?
Someone receiving corticosteroid drugs
83
What are basophils and what do they contain?
They are phagocytes and contain heparin, histamines and serotonin.
84
What are tissue basophils also know as ?
Mast cells
85
What are basophil counts used to analyze?
Allergic reactions
86
What can cause basophils to increase?
An alteration in bone marrow functions like leukemia or Hodgkin's disease
87
What can cause a decrease in basophils?
Corticosteroid drugs, allergic reactions and acute infections
88
What are monocytes claim to fame and what do they do?
They are the largest cells in normal blood. They act as phagocytes and are the body's 2nd line of defense against infection
89
What do phagocytic monocytes produce?
The antiviral substance - interferon
90
What diseases can cause a monocytosis?
TB, malaria, RM spotted fever, monocytic leukemia, chronic ulcerative colitis and regional enteritis
91
What are the primary components of the body's immune system?
Lymphocytes
92
What are lymphocytes the source of?
Serum immunoglobulins and cellular immune response
93
Lymphocytes play an important role in?
Immunologic reactions
94
What can cause a decrease/increase in lymphocytes?
Increase - Viral infections and TB | Decrease - Lymphocytic leukemia, HIV, corticosteroids and other immunosuppressive drugs
95
What are platelets?
Cell fragments formed in the bone marrow that circulate throughout the bloodstream
96
What is the role of platelets?
They play a critical role in the body's ability to help blood clot
97
What is a decrease in platelets called?
Thrombocytopenia
98
When is thrombocytopenia diagnosed?
When the platelet count goes below 50,000.
99
What can happen when the platelet count drops below 20,000?
Can result in spontaneous bleeding and death

PA final EXAM (9 decks)

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