Complementation Flashcards

1
Q

there can be many ___ at the same ___ and many ___ acting on the same ___

A

alleles, locus

loci, trait

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2
Q

+ means

A

wild-type

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3
Q

different alleles are indicated how?

A

superscripts

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4
Q

2 homozygous individuals w/ different recessive alleles at the same locus will…

A

have heterozygous offspring with a recessive phenotype

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5
Q

often mutations at different loci can give….

A

identical or nearly identical phenotypes

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6
Q

suppose you have 2 recessive mutant strains w/ same phenotype. they could be due to…

A

mutations at the same locus

2 different loci acting on the same trait

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7
Q

double heterozygote offspring

A

2 individuals with recessive homozygotes at different loci can fix each other

normal phenotype

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8
Q

how to tell if the mutation is caused by one locus or different loci?

A

cross them

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9
Q

offspring of the mutant phenotype caused by 2 mutations at the same locus…

A

will have the same mutant phenotype

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10
Q

offspring of the mutant phenotype caused by mutations at 2 different loci…

A

will be wild type

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11
Q

complementation

A

when 2 recessive homozygotes produce wild-type offspring

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12
Q

when complementation occurs how many loci are involved?

A

2

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13
Q

noncomplementation is when the offspring…

A

look like the recessive parents

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14
Q

alleles at the same locus are called

A

complementation group

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15
Q

complementation group

A

mutations that don’t complement eachother

mutants lying within the same cistron (noncomplementation group)

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16
Q

mutant screen asks

A

how many different loci are involved when all these lines have the same phenotype?

17
Q

how to do a mutant screen?

A

mutate many flies (make grandchildren homozygous by inbreeding)

keep looking for same recessive phenotype

18
Q

pleiotropy

A

multiple traits caused by the same gene

one mutation w/ multiple effects

19
Q

examples of pleiotropy

A

Waardenburg Syndrome

Nail-Patella Syndrome

Cystic Fibrosis

20
Q

incomplete penetrance

A

does the effect show up at all?

21
Q

variable expressivity

A

how much does it show up? is it mild or severe?

22
Q

epistasis

A

the effect of alleles of one gene may depend on the alleles of another gene

multiple loci working together to control a trait

ex. mouse fur color

23
Q

exception to complementation

A

interallelic complementation