Complement cascade Flashcards
1
Q
C1INH
A
inhibits C1
2
Q
C4BP
A
disrupts classical C3 convertase, binds to C4b of C3 convertase, displaces C2a fragment, making C4b susceptible to factor I cleavage
3
Q
Factor H
A
inhibits alternative C3 convertase, binds to C3b, making susceptible to factor I cleavage
4
Q
Factor I
A
Cleaves C3b and C4b
5
Q
DAF
A
Disrupts C3 convertases
6
Q
MCP
A
Disrupts C3 convertases, binds to C3b and C4b to make them susceptible to Factor I cleavage
7
Q
CD59
A
Inhibits MAC formation
8
Q
Factor P
A
stabilizes alternative C3 convertase
9
Q
CR1
A
binds to C3b and C4b making them susceptible to Factor I cleavage
10
Q
deficiency of C1NH
A
HANE syndrome, hereditary angioneurotic edema (systemic edema because of overproduction of anaphylatoxins), treat with C1NH therapy
