B cell mediated immunity

Question 1

Which antibody is found primarily in the circulation?

Answer 1

IgM

Question 2

Which antibody is found in the highest concentration in the interstitial fluid of the lymph node?

Answer 2

IgG

Question 3

Which antibody is the only type that is actively transported from the circulation into extravascular spaces?

Answer 3

IgG

Question 4

Which antibody is efficiently transported into mucosal secretions?

Answer 4

IgA

Question 5

Which antibody underlies the epithelial tissues of the body?

Answer 5

IgE

Question 6

Capsular polysaccharides are what type of antigen?

Answer 6

T indepenent antigens (type II)

Question 7

What is the effector cell for the antibody dependent cell mediated cytotoxicity (ADCC)

Answer 7

NK cells

Question 8

NK cells have Fc receptors that recognize?

Answer 8

IgG1, IgG3 (which then causes degranulation and apoptosis)

Question 9

NK cells will also recognize host cells that express stress proteins or do not express?

Answer 9

MHC Class I molecules

Question 10

IgA passively transferred will protect a child against what?

Answer 10

Viral (intracellular) pathogen introduced via inhalation into lung

Question 11

IgA neutralizes pathogens in the lumens of ?

Answer 11

respiratory, gastrointestinal, and urinary tracts of the body

Question 12

Extravascular fluid will primarily have what antibody?

Answer 12

IgG

Question 13

Antibodies found mostly in tears or lumens of the gut or respiratory tract?

Answer 13

IgA

Question 14

What receptor transports IgA into mucosal secretions?

Answer 14

polyIg receptor

Question 15

The Brambell receptor is associated with what antibody type?

Answer 15

IgG

Question 16

B cell activation requires recognition of cognate determinant followed by T cell help. Which signal is supplied by T cells?

Answer 16

CD40L (t cell) –> CD40 (B cell) and cytokines that drive class switching

Question 17

A patient without CD40 would have what type of response fully intact?

Answer 17

CD8 T cell response (doesn’t help B cell or produce adaptive immune humoral response)

Question 18

Igalpha/Igbeta is the signal transduction unit of the ?

Answer 18

B cell receptor

Question 19

A nonfunctional Igalpha/Igbeta will cause

Answer 19

B cell activation to be impossible –> B cells would die during development

Question 20

Which interleukin is most responsible for driving isotope switching of differentiating B cells (during germinal center reaction) to one of the IgA isotopes

Answer 20

IL-5

Question 21

Which deficiency would have no impact on the number of B cells and T cells but would result in the patient being unable to class switch or go through affinity maturation?

Answer 21

Cytidine deaminase AID deficiency

Question 22

If a patient had deficiency in Bruton’s tyrosine kinase or IL-7, the patient would have near absence of what?

Answer 22

B cells

Question 23

If patient had normal numbers of B cells and T cells and normal lymph node structure, but no germinal centers, what deficiency would they have?

Answer 23

CD40L deficiency (helper T cells can’t activate B cells)

Question 24

Normal numbers of B and T cells but unable to produce effector T cells

Answer 24

IL-2 deficiency (results in total lack of germinal centers and CTL responses)

Question 25

TAP-1 and TAP2 deficiency would cause a patient to be unable to load peptides onto

Answer 25

MHC Class I molecules

Question 26

smaller B and T cell repertoires would probably be a result of which deficiency?

Answer 26

TdT deficiency

Question 27

Which deficiency would result in a child having recurrent infections because of the lack of B cell maturity being possible?

Answer 27

Bruton’s tyrosine kinase