Complement Flashcards
1
Q
C3b
A
Opsonin
Clearance of immune complexes
2
Q
C5a>C3a(»C4a)
A
Anaphylatoxin
Activates vascular endothelium
Chemoattractant
Activates phagocytes (recruitment/respiratory burst)
3
Q
C5b-C9 (MAC)
A
Cellular damage and lysis
4
Q
Phagocytic recruitment
A
Anaphylatoxin: C5a > C3a»_space; (C4a)
Activation of vascular endothelium: C5a > C3a
Chemoattractant (C5a most potent)
5
Q
Phagocytic killing
A
Activates phagocytes: C5a»_space;>C3a
Opsonization: C3b (binds CR1 receptor on phagocytes)
6
Q
Direct damage/killing
A
Cellular damage and lysis by MAC (C5b6789)
7
Q
Clearance of immune complexes
A
C3b on immune complex
CR1 on erythrocyte, macrophages in liver and spleen
