Complement

Question 1

MAC defends against what type of bacteria?

Answer 1

Gram negative

Question 2

Activation of classic pathway

Answer 2

IgG or IgM

Question 3

Activation of alternative pathway

Answer 3

Microbe surface molecules

Question 4

Activation of lectin pathway

Answer 4

Mannose or other sugars on microbe surface

Question 5

Function of C3b

Answer 5

Opsonization, clear immune complexes

Question 6

Function of C3a

Answer 6

Anaphylaxis

Question 7

Function of C5a

Answer 7

Anaphylaxis, neutrophil chemotaxis

Question 8

Function of C5b-9

Answer 8

Cytolysis by MAC

Question 9

Primary opsonins in bacterial defense

Answer 9

C3b and IgG

Question 10

Inhibitors

Answer 10

Decay-accelerating factor (DAF) and C1 esterase inhibitor

Question 11

C1 esterase inhibitor deficiency

Answer 11

Hereditary angioedema

Question 12

What is contraindicated in C1 esterase inhibitor deficiency?

Answer 12

ACE-Inhibitors

Question 13

C3 deficiency manifestations

Answer 13

Severe, recurrent pyogenic sinus and respiratory tract infections; increased susceptibility to type III hypersensitivity reactions

Question 14

C5-C9 deficiencies

Answer 14

Recurrent Neisseria bacteremia

Question 15

DAF (GPI anchored enzyme) deficiency

Answer 15

Complement-mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria (PNH)