commonly used drugs Flashcards

1
Q

ASA system

A

 System to estimate medical risk
 Originally designed for general anesthesia patient
 Commonly known as ASA Classification

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2
Q

ASA classes

A

1,2,3,4,5,6,E

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3
Q

ASA 1

A

Normal, Healthy patient without systemic disease

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4
Q

ASA 2

A

Mild systemic disease

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5
Q

asa 3

A

Severe systemic disease, limits activity but no
incapacitating

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6
Q

asa 4

A

incapacitating systemic disease that is constant threat to life

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7
Q

asa 5

A

Not to survive 24 hours with/without operation

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8
Q

asa 6

A

Brain-dead patient awaits for organ donation

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9
Q

asa e

A

Emergency operation
 Precedes number status ( i.e. ASA E-II)

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10
Q

ASA Classification, Definition
 Normal or Usual:
 Distress:

A

 Normal or Usual: Ability to climb one flight of stairs or walk 2 level city blocks
 Distress: Undue fatigue, shortness of breath, or chest pain

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11
Q

asa 2 examples

A

 Type II or Non insulin dependent diabetes
 Well controlled epilepsy ( no seizure in the past year)
 Well controlled asthma
 Hypothyroid / Hyperthyroid patient under treatment and currently euthyroid
 Healthy pregnant female
 > 60 y/o patient
 Extreme phobic patient
 Drug allergy or multiple allergies patient
 Systolic 140/159mmHg and diastolic 90-94mmHg
may proceed with tx

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12
Q

asa 3 examples

A

 Type I DM, well controlled patient
 Symptomatic thyroid disease patient
 >6 months without any residual complication
 Myocardial infarction
 CVA
 BP (169-199) systolic / (95-114) diastolic
 Epilepsy: Several seizures per year
 Asthma,: Stress / exercise induced / hospitalization
 Angina Pectoris (stable angina)
 CHF with
 orthopnea ( > 2 pillow)
 Ankle edema
 COPD

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13
Q

ASA III
 No S/S of distress at rest, BUT?
 tx mod
 tx?

A

 No S/S of distress at rest, BUT not under stressful situation
 Serious treatment modification is needed
 Yellow light for treatment ( proceed with caution

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14
Q

ASA IV
 S/S of their medical problem when?
 Their medical problem has greater significance than?
 OK for ?
 If invasive dental treatment is needed?
 go ahead?

A

 S/S of their medical problem at REST
 Their medical problem has greater significance than
elective dental treatment
 OK for non invasive dental emergency treatment
 If invasive dental treatment is needed  hospital
 Red light for treatment ( DON’T Proceed)

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15
Q

asa 4 examples

A

Unstable Angina
 <6 months without any residual complication
 Myocardial infarction
 CVA
 BP >200 systolic / >115 diastolic
 Uncontrolled dysrhythmias
 Severe CHF or COPD
 Wheel chair bound or need supplemental oxygen
 Uncontrolled epilepsy
 Uncontrolled IDD

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16
Q

ASA V
 def
 Hospitalized patient with?
 dental care?

A

ASA V
 Moribound patient not to expect to survive 24 hours\
 Hospitalized patient with end-stage disease
 Palliative dental care

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17
Q

Examples of ASA V Patients

A

 Hospital heart valve surgery patients in need of dental
extractions
 Hospital patients with end-stage organ disease in need
of palliative dental care

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18
Q

Patient Demographic in asa classes

A

Patient Demographic
 ASA I or II = 85% dental patients
 ASA III or IV = 14% dental patients

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19
Q

Sedation
 Definition

A

 Reduction of irritability or agitation by administration of
sedative drugs, generally to facilitate a medical procedure

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20
Q

MO Dental Board
 Moderate Sedation forms
 sedations?
 Site Certificate for?

A

 Moderate Sedation: Enteral, Parenteral, Pediatric
 Deep Sedation / General
 Site Certificate for each typ

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21
Q

Pediatric Patient Definition and sedations

A

 A patient aged twelve (12) or under. The use of preoperative sedatives for children (aged twelve (12) and under) except in extraordinary situations must be avoided due to the risk of unobserved respiratory obstruction during transport by untrained individuals.

 Children (aged twelve (12) and under) can become moderately sedated despite the intended level of minimal sedation; should this occur, the guidelines for moderate sedation apply.

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22
Q

Minimal Sedation (Anxiolysis)

A

 Minimal sedation (Anxiolysis)—A minimally depressed level of consciousness produced by a pharmacological method, which retains the patient’s ability to independently and continuously maintain an airway and respond normally to tactile stimulation and verbal command. Although cognitive function and coordination may be modestly impaired, ventilatory and cardiovascular functions are unaffected. Note: In accord with this particular definition, the drug(s) and/or techniques used should carry a margin of safety
wide enough never to render unintended loss of consciousness. Further, patients whose only response is reflex withdrawal from repeated painful stimuli would not be considered to be in a state of minimal sedation. When the intent is minimal sedation for adults, the appropriate initial dosing of a single enteral drug is no more than the maximum recommended dose (MRD) of a drug that can be prescribed for unmonitored home use

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23
Q

minimal sedations for kids

A

The use of preoperative sedatives for children (aged twelve (12) and under) except in extraordinary
situations must be avoided due to the risk of unobserved respiratory obstruction during transport by
untrained individuals. Children (aged twelve (12) and under) can become moderately sedated despite the
intended level of minimal sedation; should this occur, the guidelines for moderate sedation apply.

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24
Q

NO with anxiolytics

A

Nitrous oxide/oxygen may be used in combination with a single enteral drug in minimal sedation.

Nitrous oxide/oxygen when used in combination with sedative agent(s) may produce minimal, moderate, or deep sedation or general anesthesia.

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25
Q

Moderate Sedation (Conscious Sedation)
 A drug induced depression of?
 Generally, no interventions are required to?
 Cardiovascular function?

A

Moderate Sedation (Conscious Sedation)
 A drug induced depression of consciousness during which
patients respond purposefully to verbal commands, either alone
or accompanied by light tactile stimulation.
 Generally, no interventions are required to maintain a patent
airway, and spontaneous ventilation is adequate.
 Cardiovascular function is usually maintained

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26
Q

Deep Sedation
 A drug-induced depression of ? during which?
 The ability to independently maintain ventilatory function?
 Patients may require assistance in?
 Cardiovascular function?

A

Deep Sedation
 A drug-induced depression of consciousness during which
patients cannot be easily aroused but respond purposefully
following repeated or painful stimulation.
 The ability to independently maintain ventilatory function may be
impaired.
 Patients may require assistance in maintaining a patent airway
and spontaneous ventilation may be inadequate.
 Cardiovascular function is usually maintained.

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27
Q

Qualified Sedation Provider
 Qualified sedation provider—Any of the following who have
satisfied the provisions of this rule:

A

 1. A currently licensed dentist in Missouri with a valid permit to
administer enteral, parenteral, or pediatric moderate sedation
 2. A currently licensed anesthesiologist
 3. A currently licensed certified registered nurse anesthetist.

28
Q

Common Medication used in IV Sedation

A

 Barbiturate
 Propofol
 Ketamine
 Benzodiazepine
 Opioids

29
Q

Opioids General Properties
 Desirable Effects

A

 Analgesia
 Sedation
 Euphoria
 Anti-tussive

30
Q

Undesirable Effects of opioids

A

 Respiratory Depression
 Coma
 Emesis
 Constipation
 Histamine release
 Potential for addiction

31
Q

Miosis
 Mechanism of action
 Significance?
 All Addicts demonstrate?

A

 Mechanism of action
○ Edinger-Westphal nucleus of Oculomotor nerve
○ Enhanced parasympathetic stimulation
 Significance?
○ Most other causes of coma and respiratory depression produce
mydriasis (dilation of pupil)
 All Addicts demonstrate pin-point pupils

32
Q

Opioids Mechanism of Action

mu, kappa, delta, sigma

A
33
Q

endogenous opioids

A

 Endorphins
 Enkephalins
 Dynorphins

34
Q

Morphine
 The Gold Standard?
 Pharmacology
 routes?
 moa?
 lipophilicity?
 Onset? peak?
 T ½
 Duration of action :
 Do not give to?

A

 The Gold Standard of pain med

 IM / IV
 Hyperpolarize nerve cell, ↓release of substance P
 Least lipophilic  minimum crossing to BBB
 Onset 5-10mins, peak within 30mins
 T ½ 1.5 – 2 hours
 Duration of action : 4-6 hours
 Do not give to neonate (unable to conjugate)

35
Q

morphine metabolism

A

 Conjugate with glucuronic acid
○ Morphine-6-glucuronide (potent analgesic)
○ Morphine-3-glucuronide (inactive)

36
Q

Morphine
 Elimination

A

 End product eliminated by kidney
 Renal failure patient may have narcosis and vent failure for days !

37
Q

morphine adrs

A
38
Q

Fentanyl
potentcy?
 Pharmacology
 routes?
 effects?
 lipophilicity?
 Onset? peak effect in?
 Duration

A

Fentanyl
 100X potency of morphine

 Oral / IV / Transdermal
 Analgesic and Sedative effect
 High Lipid solubility  rapid onset / short duration
 Onset of action < 60 sec with peak effect in 2 – 5 mins
 Duration 30 – 60 mins

39
Q

fent Metabolism

A

 Inactive metabolite
○ Remember the “end “ of the effect is due to redistribution!!
○ Fentanyl will accumulate in body fat with repeated injections

40
Q

Fentanyl
 Elimination

A

 Little effect on renal patient
 Clearance dependent on hepatic blood flow

41
Q

fent adr

A

 No histamine release like morphine
 Rigid Chest Syndrome
○ After large drug bolus !!

42
Q

Naloxone (Narcan)
 Mechanism of Action

A

 Competitive antagonist at opioid receptors
 Greater affinity for μ receptors than κ or δ receptor

43
Q

naloxone Pharmacology
 Reversal of ?
 rate?
 duration?
○ why?
 T ½
○ implication

A

 Reversal of endogenous or exogenous opioid compound
 Rapid antagonizing (1-2 min)
 Brief duration of action (30-45 mins) IV
○ Rapid redistribution from CNS
 T ½ is only 30–80 mins
○ Respiratory depression may linger despite “alert/awake” appearance

44
Q

naloxone dose

A

 IV administration of 0.4mg IV (Titrate to effect !!!)

45
Q

Naloxone (Narcan)
 Recommended usage
 Any suspicion of?
○ Support?
○ Check?
 Continue sluggish response
○ Rule out?
○ Consider giving?

A

 Any suspicion of OD
○ Support respiration (O2 and continue monitoring)
○ Check oxygen saturation, vital signs
 Continue sluggish response
○ Rule out hypoglycemic shock, CVA, Psychotic episode
○ Consider giving IM, if concern for re-sedation give 0.4mg IM

46
Q

naloxone adrs

A

 Abrupt reversal = Excessive catecholamine release
○ tachycardia, hypertension, ventricular irritability
 May antagonize Clonidine
 Nausea/Vomiting may be observed

47
Q

Benzodiazepines
General properties

A

 Sedation
 Anxiolysis
 Muscle relaxation
 Anterograde amnesia
 Anticonvulsant effect

48
Q

common side effects of benzodiazepines

A

 Fatigue
 Drowsiness
 Respiratory depression !

49
Q

are benzos an analgesiac?

A

no

50
Q

Benzodiazepines
Mechanisms of Actions

A

 Enhances inhibitory effect of neurotransmitters
 Facilitates GABA receptor binding
 ↑membrane conductance of Chloride ions
enhances inhibitory effect of GABA

51
Q

Diazepam
 IM injection?
 Pharmacology
 insoluble in? leads to>
 CNS uptake?

A

Benzodiazepines
Diazepam
 IM injection of diazepam is painful and unreliable
 Pharmacology
 Water-insoluble therefore…..
 Propylene glycol + Sodium Benzoate added but pain upon injection
 Rapid uptake by CNS due to high lipid solubility

52
Q

diazepam metab

A

 Hepatic microsomal enzyme = Desmethyldiazepam + Oxazepam
 Desmethyldiazepam is metabolized slowly =sustained effects !
 Phase 1 metabolites of diazepam are pharmacological active

53
Q

diazepem elimination

A

Long half-life 30 hours

54
Q

Midazolam
 Oral Administration is?
 Pharmacology:
 localirritant?
 potnent?
 solubilities?
○ at physiologic pH?

A

Midazolam
 Oral Administration is NOT approved by FDA but commonly used
 No local irritation
 2-3X more potent than diazepam
 Water soluble at low pH
 Lipid soluble at high pH
○ Imidazole ring closes at physiologic pH

55
Q

Midazolam
metabolism, elim, placenta, paradox?

A
56
Q

Flumazenil (Romazicon)
 Mechanism of Action

A

 Competitive antagonist of benzodiazepine receptors

57
Q

flumazenil usage

A

Usage
 Reversal of benzodiazepine sedation and/or overdose
 Prompt (<1min) hypnotic reversal, Amnesia is ?
 Respiratory depression may linger despite “alert/awake” appearance

58
Q

flumazenil Dosage
 IV administration of ? until reversal
 repeated doses, why>
 T ½

A

 IV administration of 0.2mg every min until reversal
 Due to rapid hepatic clearance, repeat dose may be needed in 1-2 hours
 T ½ is only ~ 1 hour

59
Q

flumazenil Side Effects
 May induce?
 Increases?
 GI

A

 May induce seizure activity
 Increase Catecholamines
○ ↑ BP and heart rate
 Nausea/Vomiting may be observed

60
Q

 The most Frequently administered General Anesthesia induction
agent

A

Barbiturates

61
Q

Barbiturates
 Mechanism of Action:

A

 Enhance GABA inhibitory neurotransmitter

62
Q

barbs site of actions

A

Depress reticular activating system
○ Polysynaptic network responsible for consciousness

63
Q

Common Barbiturates

A

 Thiopental
 Methohexital (Brevital)
 Phenobarbital

64
Q

Propofol / Diprivan
 Mechanism of action, results in?
 Largely replacing?

A

 Enhance GABA inhibitory function = ↑Cl channel = increases hyperpolarization of cell membrane
 Results Rapid onset of unconsciousness
 Arterial and venous dilatation
 Largely replacing Thiopental (Barbiturates)

65
Q

Ketamine
 used for?
 moa
 affects?
 Sympath?

A

 General Anesthesia Medicine
 Selective NMDA receptor blocker
 Dissociative, Hallucinogenic and Amnesic Effect
 Sympathomimetic medicine (ADRs)

66
Q

ketamine cons

A

 Hallucinogenic, Nightmare emergence, Increase Salivary flow