Common Obstructive Respiratory Conditions Flashcards

1
Q

describe the internal structure of the trachea

A
  • anteriorly has c-shaped cartilagenous rings
  • posteriorly has smooth muscle
  • pseudostratified ciliated columnar epithelial cells (cilia)
  • goblet cells
  • mucous glands
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2
Q

describe the internal structure of bronchi

A
  • cartilage rings and smooth muscle
  • pseudostratified ciliated columnar epithelial cells
  • gobet cells
  • mucous glands
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3
Q

describe the internal structure of bronchioles

A
  • no cartilage
  • well defined smooth muscle
  • cuboidal epithelial cells
  • no goblet or mucous glands
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4
Q

which cell structures make up an airway

A
  • ciliated cells
  • goblet cells
  • mucous glands
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5
Q

what is the function of cell structures that amke up an airway

A
  • production of mucus
  • movement of mucus
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6
Q

why is effective mucociliary transport important

A
  • ensures no blockages of sputum so gas exchnage can occur
  • and helps prevent infection
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7
Q

what can impair effective mucociliary transport

A
  • smoking
  • air pollution
  • anaesthesia
  • pathologies/ disease/ infections
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8
Q

what problems can things like smoking, anaesthesia, air pollution and infections cause

A
  • blockages in airways
  • stagnent secretions
  • can in turn cause infections
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9
Q

how is an obstructive CVR conditon characterised

A

a limitation of airflow due to a partial or complete obstruction

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10
Q

what are the charactersitics of an obstructive CVR condition

A
  • initially total lung capacity is normal
  • normal FVC
  • reduced expiratory flow rate
  • FEV1/ FVC <0.80
  • inflammation and/ or thickening in/ of airway walls
  • decrease of tissue mass
  • loss of lung parenchyma (a.k.a. alveoli)
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11
Q

what are common causes of an obstructive CVR condition

A
  • COPD
  • brochiectasis
  • cystic fibrosis
  • asthma
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12
Q

what are common sites for infection

A
  • sinuses (sinusitis)
  • tonsils (tonsilitis)
  • pharynx (pharyngitis - sore throat)
  • larynx (laryngitis)
  • trachea (tracheitis)
  • pleura (pleurisy - inflammation of pleura often vaused by infection)
  • bronchioles (brochiolitis)
  • bronchi (brochitis)
  • alveoli & surrounding lung (pneumonia)
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13
Q

what are the two types of chest infections

A
  • upper respiratory tract infection (URTI)
  • lower respiratory tract infection (LRTI)
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14
Q

how are URTIs often caused

A

infection of sinuses, airways or throat

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15
Q

how are LRTIs often caused

A

acute bronchitis or pneumonia

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16
Q

how can chest infections spread

A

direct and indirect contact via droplets

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17
Q

what are symptoms of a chest infection

A
  • increased productivity of cough
  • dyspnoea
  • coryzal symptoms
18
Q

what are coryzal symptoms

A
  • nasal stuffiness
  • runny nose
  • sneezing
  • sore throat
  • cough
19
Q

what is dyspnoea

A

sensation of running out of the air and of not being able to breathe fast enough or deeply enough

20
Q

describe pneumonia
(obstructive)

A

is the inflammation of lung tissue usually due to infection with bacteria

21
Q

what are the 2 types of pneumonia

A
  1. lobar pneumonia: specific area of consolidation
  2. bronchial pneumonia: inflames alveoli
22
Q

what is consolidation

A

infected tissue whihc is stuck together

23
Q

describe how the severity of pneumonia is determined

A

using CURB-65 score
- 0 = low severity, likely for home treatment.
- 1-2 = moderate severity, consider hodpital referral
- 3-4 = high severity, rgent hospital admission

24
Q

describe bronchitis
(obstructive)

A

inflammation and infection of the bronchi

25
Q

what is bronchitis most often caused by

A

smoking

26
Q

what are the symptoms of bronchitis

A
  • increased sputum production (usually discoloured)
  • wheeze
  • similar to URTIs
27
Q

define emphysema
(obstructive)

A

damage to the alveoli causing them to lose thier elasticity.

28
Q

what does emphysema result in

A

alveoli…
- collapse
- destruction
- narrowing
- overinflation
- stretching

29
Q

What is bronchiectasis defined by
(obstructive)

A

Permanent and abnormal widening of the bronchi

30
Q

Why does bronchiectasis occur

A

Due to chronic airway infection and inflammation

31
Q

How is bronchiectasis characterised.

A

Mild to moderate airflow obstruction that tends to worsen over time

32
Q

What are some symptoms of bronchiectasis

A
  • Intermittent episodes of expectoration
  • infection localised to the region of lung that is affected
  • persistant expectoration of large volumes of purulent sputum (causing blockages)
33
Q

what is prulent sputum

A

off-white, yellow or green, and opaque.
- usually indicates the presence of large numbers of white blood cells,

34
Q

what is asthma caused by
(obstructive)

A

inflammation of the airway due to smooth muscle contracting, causing the lumen to narrow

35
Q

what causes the inflammation of airways for asthma

A
  • smooth muscle contracts and causes lumen to narrow
36
Q

how can asthma occur

A

randomly or in response to a trigger

37
Q

what are some asthma triggers

A
  • allergies (dust mites, animal fur, pollen)
  • smoke
  • pollution
  • cold air
  • exercise
  • infections like colds or flu
38
Q

what are the main symptoms of asthma

A
  • wheeze
  • breathlessness
  • chets ightness
  • coughing
39
Q

how do people get cystic fibrosis
(obstructive)

A

the recessive gene has to be inhertied form both parents

40
Q

what gene causes cystic fibrosis

A

a faulty gene (CFTCR) which impairs the movement of salt and water betwene cells in the body which results in sticky mucus build up in the lungs and digesitve system