Common Indications

Question 1

What pregnancy complications increase with age

Answer 1

Aneuploidy, hypertension, pre eclampsia, gestational diabetes, preterm birth, still birth, multiples, decreased fertility

Question 2

What is cutoff for advanced age with twin pregnancies

Answer 2

32

Question 3

What is the mechanism behind aneuploidy increasing with age

Answer 3

Oogenesis, specifically non disjunction during maternal meiosis one

Question 4

What is the cutoff for advanced paternal age

Answer 4

40

Question 5

What is associated with advanced paternal age

Answer 5

De novo mutations, certain birth defects, autism, bipolar disorder, schizophrenia

Question 6

What is the risk for aneuploidy if the patient had a previous pregnancy with an aneuploidy

Answer 6

1% + age related risk

Question 7

How would you discuss recurrence risks for birth defects

Answer 7

Use empirical data unless known genetic cause

Question 8

What is the prevalence of intellectual disability, & what are the recurrence risks for ID & autism

Answer 8

1%, 3-14%, 2-8%

Question 9

What are common referral indications to a prenatal genetic counselor

Answer 9

Age related risks, personal & family hx, consanguinity, ultrasound findings, teratogen, recurrent loss or infertility, preconception