Common Features in Brain Neurodegeneration

Question 1

what do all neurodegenerative diseases involve?

Answer 1

rogue proteins

Question 2

what are the 2 major ways cells remove unwanted proteins?

Answer 2

Chaperone-mediated Autophagy (CMA)
the Ubiquitin-Proteasome System (UBS)

Question 3

UBS

Answer 3

for short lived/soluble proteins
breaks down proteins by proteasomes

Question 4

CMA

Answer 4

for long lived/insoluble proteins
breaks down proteins by creating autophagosomes that fuse with lysomes, forming autososomes