Common Drug-Drug Interactions

Question 1

Warfarin and NSAIDS

Answer 1

Combined – gastrointestinal bleeding (GI) increases significantly

Question 2

Warfarin and Antibiotics

Answer 2

Combined – increases the risk of over-anticoagulation and bleeding

Question 3

Oral Contraceptives and Antibiotics

Answer 3

Combined – increases the likelihood of contraceptive failure and risk of pregnancy

Question 4

Vasodilators//Nitrates and PDE-5 Inhibitors

Answer 4

Combined – blood pressure can drop to a dangerously low level

Question 5

Lithium and Diuretics

What happens when diuretics are taken, while on lithium therapy?

Answer 5

Combined – lithium concentration in the blood increases, and can lead to lithium toxicity, and death (severe cases)