Combined Adrenergic and Anti-Cholinergic Bronchodilators

Question 1

Name the 6 Combined Adrenergic and Anti-Cholinergic Bronchodilators

Generic Names (6)

Answer 1

1. Ipratropium Bromide/Albuterol
2. Aclidinium Bromide/Formoterol
3. Glycopyrrolate Bromide/Formoterol
4. Glycopyrrolate Bromide/Indacaterol
5. Umeclidinium Bromide/Vilanterol
6. Tiotropium Bromide/Olodaterol

Question 2

Name the 6 Combined Adrenergic and Anti-Cholinergic Bronchodilators

Trade Names (6)

Answer 2

1. SVN: DuoNeb, MDI: Combivent
2. Duaklir Pressair
3. Bevespi Aerosphere
4. Ubitron Neohaler
5. Anoroa Ellipta
6. Stiolto Respimat

Question 3

Combined Adrenergic and Anti-Cholinergic Bronchodilators

What are the Receptors

Answer 3

Muscarinic and B2

Question 4

Combined Adrenergic and Anti-Cholinergic Bronchodilators

What is the Mode of Action

Answer 4

Muscarinic: Blocks “ACH” Acetylcholine from binding to “M” Muscarinic Receptors causing dilation of Airways

B2: Relaxes bronchial smooth muscles, and stimulates mucociliary activity

Question 5

Combined Adrenergic and Anti-Cholinergic Bronchodilators

What is the Duration

Answer 5

6 - 24 Hours

Question 6

Combined Adrenergic and Anti-Cholinergic Bronchodilators

What are the Hazards (10)

Answer 6

1. Increase HR
2. Increase BP
3. Tremors
4. Palpitations
5. Dizziness
6. Nervousness
7. Hypokalemia
8. Hyperglycemia
9. Dry mouth
10. Pupillary Dilation

Question 7

Combined Adrenergic and Anti-Cholinergic Bronchodilators
Ipratropium Bromide/Albuterol

Trade Names
Dosages

Answer 7

Trade Names:
SVN: DuoNeb, MDI: Combivent

Dosages:
SVN: 0.5 mg/2.5mg
DPI: 18 mcg/9 mcg/puff 2 puff

Question 8

Combined Adrenergic and Anti-Cholinergic Bronchodilators
Aclidinium Bromide/Formoterol

Trade Names
Dosages

Answer 8

Trade Names:
Duaklir Pressair

Dosages:
DPI: 400 mcg/12 mcg inhalation BID

Question 9

Combined Adrenergic and Anti-Cholinergic Bronchodilators
Glycopyrrolate Bromide/Formoterol

Trade Names
Dosages

Answer 9

Trade Names:
Bevespi Aerosphere

Dosages:
MDI: 9 mcg/inhalation and 4.8 mcg inhalation indacaterol BID

Question 10

Combined Adrenergic and Anti-Cholinergic Bronchodilators
Glycopyrrolate Bromide/Indacaterol

Trade Names
Dosages

Answer 10

Trade Names:
Ubitron Neohaler

Dosages:
DPI: 15.6 mcg/inhalation and 27.5 mcg/inhalation indacaterol BID

Question 11

Combined Adrenergic and Anti-Cholinergic Bronchodilators
Umeclidinium Bromide/Vilanterol

Trade Names
Dosages

Answer 11

Trade Names:
Anoroa Ellipta

Dosages:
DPI: Umeclidinium 62.5 mcg/inhalation
and Vilanterol 25 mcg/inhalation, once daily

Question 12

Combined Adrenergic and Anti-Cholinergic Bronchodilators
Tiotropium Bromide/Olodaterol

Trade Names
Dosages

Answer 12

Trade Names:
Stiolto Respimat

Dosages:
SMI: Tiotropium 2.5 mcg/inhalation
and Olodaterol 2.5 mcg/inhalation, 2 inhalations once daily