Combination Drugs

Question 1

Ipratropium & Albuterol Sulfate

(Duoneb)

Answer 1

Albuterol sulfate is a β2-adrenergic bronchodilator; Ipratropium bromide is an anticholinergic bronchodilator

INDICATIONS

Treatment of bronchospasm associated with COPD in patients requiring more than one bronchodilator.

DOSAGE AND ADMINISTRATION

• one 3 mL vial administered qid via nebulization with up to 2 additional 3 mL doses qd, prn.
• can be continued as medically indicated to control recurring bouts of bronchospasm.
• via jet nebulizer connected to an air compressor with an adequate air flow, equipped with a mouthpiece or suitable face mask.

DESCRIPTI​ON

The active components in DuoNeb® (ipratropium bromide and albuterol sulfate) Inhalation Solution are albuterol sulfate and ipratropium bromide.

Albuterol sulfate is a β2-adrenergic bronchodilator

• salt of racemic albuterol and a relatively selective β2-adrenergic bronchodilator chemically described as α1-[(tert-butylamino)methyl]-4-hydroxy-mxylene-α, α’-diol sulfate (2:1) (salt). It has a molecular weight of 576.7 and the empirical formula is (C13H21NO3)2•H2SO4.
• It is a white crystalline powder, soluble in water and slightly soluble in ethanol.

Ipratropium bromide is an anticholinergic bronchodilator chemically described as

• 8azoniabicyclo [3.2.1]-octane, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8methyl-8-(1methylethyl)-, bromide, monohydrate (endo, syn)-, (±)-; a synthetic quaternary ammonium compound, chemically related to atropine.
• It has a molecular weight of 430.4 and the empirical formula is C20H30BrNO3•H2O. It is a white crystalline substance, freely soluble in water and lower alcohols, and insoluble in lipophilic solvents such as ether, chloroform, and fluorocarbons.

Question 2

What does Ipratropium & Albuterol Sulfate (Duoneb) treat?

Answer 2

COPD