Colposcopy Clinic

Question 1

What are the most common strains of HPV to cause cervical cancer?

Answer 1

HPV 16 and 18

Question 2

What do HPV 16 and 18 produce that lead to cervical cancer?

Answer 2

E6 and E7 which inhibit p53 and pRB (tumour suppressor genes)

Question 3

What is the depth of CIN 1?

Answer 3

1/3 epithelial layer

Question 4

What is the depth of CIN 2?

Answer 4

2/3 epithelial layer

Question 5

Stage 1 cervical cancer?

Answer 5

Confined to cervix

Question 6

Stage 2 cervical cancer?

Answer 6

Upper 2/3 vagina

Question 7

Stage 3 cervical cancer?

Answer 7

Lower 1/3 vagina/pelvic wall

Question 8

Stage 4 cervical cancer?

Answer 8

Bladder, rectum, beyond pelvis

Question 9

Two treatments of moderate/high grade CIN?

Answer 9

Cold coagulation (thermocoagulation)
Large loop excision of the transformational zone (LLETZ)

Question 10

After treatment of CIN, when is your next smear?

Answer 10

6 months

Question 11

How often are women called for routine smears?

Answer 11

Every 5 years

Question 12

At what age range are you asked to attend a smear test?

Answer 12

25-64

Question 13

What proportion of people still carry HPV virus after treatment?

Answer 13

1/5

Question 14

If you have had treatment for CIN, how often are you then routinely invited for a smear?

Answer 14

Every 3 years

Question 15

What is one lifestyle intervention that you can advise to clear body of HPV virus?

Answer 15

Smoking cessation

Question 16

What can CGIN develop into?

Answer 16

Adenocarcinoma

Question 17

How is CGIN treated?

Answer 17

All treated as high grade with LLETZ

Question 18

If HPV is positive but cytology negative, when is your next smear?

Answer 18

12 months