Colon

Question 1

CHEMOTHERAPY FOR ADVANCED OR METASTATIC DISEASE - CHEMOTHERAPY REGIMENS

Answer 1

mFOLFOX 6
Oxaliplatin 85 mg/m2 IV day 1
Leucovorin 400 mg/m2 IV day 1
5-FU 400 mg/m2 IV bolus on day 1, then 1200 mg/m2/d x 2 days  (total 2400 mg/m2 over 46–48 hours)IV continuous infusion 
Repeat every 2 weeks

Question 2

CHEMOTHERAPY FOR ADVANCED OR METASTATIC DISEASE - CHEMOTHERAPY REGIMENS

Answer 2

mFOLFOX7
Oxaliplatin 130 mg/m2 IV day 1
Leucovorin 400 mg/m2 IV day 1
5-FU 1200 mg/m2/d x 2 days (total 2400 mg/m2 over 46–48 hours) IV continuous infusion 
Repeat every 2 weeks

Question 3

CHEMOTHERAPY FOR ADVANCED OR METASTATIC DISEASE - CHEMOTHERAPY REGIMENS

Answer 3

FOLFOX + bevacizumab
Bevacizumab 5 mg/kg IV, day 1
Repeat every 2 weeks

Question 4

CHEMOTHERAPY FOR ADVANCED OR METASTATIC DISEASE - CHEMOTHERAPY REGIMENS

Answer 4

FOLFOX + cetuximab (KRAS/NRAS WT only)
Cetuximab 400 mg/m2 IV over 2 hours first infusion, then 250 mg/m2 IV over 60 minutes weekly
or
Cetuximab 500 mg/m2 IV over 2 hours, day 1, every 2 weeks

Question 5

CHEMOTHERAPY FOR ADVANCED OR METASTATIC DISEASE - CHEMOTHERAPY REGIMENS

Answer 5

CAPEOX
Oxaliplatin 130 mg/m2 IV day 1
Capecitabine 1000mg/m2 twice daily PO for 14 days
Repeat every 3 weeks

Question 6

CHEMOTHERAPY FOR ADVANCED OR METASTATIC DISEASE - CHEMOTHERAPY REGIMENS

Answer 6

CAPEOX + bevacizumab
Oxaliplatin 130 mg/m2 IV day 1
Capecitabine 1000mg/m2 PO twice daily for 14 days 
Bevacizumab 7.5 mg/kg IV day 1 
Repeat every 3 weeks

Question 7

CHEMOTHERAPY FOR ADVANCED OR METASTATIC DISEASE - CHEMOTHERAPY REGIMENS

Answer 7

FOLFIRI
Irinotecan 180 mg/m2 IV over 30–90 minutes, day 1
Leucovorin 400 mg/m2 IV infusion to match duration of irinotecan infusion, day 1
5-FU 400 mg/m2 IV bolus day 1, then 1200 mg/m2/d x 2 days (total 2400 mg/m2 over 46–48 hours) continuous infusion
Repeat every 2 weeks

Question 8

CHEMOTHERAPY FOR ADVANCED OR METASTATIC DISEASE - CHEMOTHERAPY REGIMENS

Answer 8

FOLFIRI + bevacizumab
Bevacizumab 5 mg/kg IV, day 1
Repeat every 2 weeks

FOLFIRI + cetuximab (KRAS/NRAS WT only) Cetuximab 400 mg/m2 IV over 2 hours first infusion, then 250 mg/m2 IV over 60 minutes weekly
or
Cetuximab 500 mg/m2 IV over 2 hours, day 1, every 2 weeks

FOLFIRI + panitumumab(KRAS/NRAS WT only) Panitumumab 6 mg/kg IV over 60 minutes, day 1 Repeat every 2 weeks

FOLFIRI + ziv-aflibercept Ziv-aflibercept 4 mg/kg IV over 60 minutes, day 1
Repeat every 2 weeks

Question 9

CHEMOTHERAPY FOR ADVANCED OR METASTATIC DISEASE - CHEMOTHERAPY REGIMENS

Answer 9

FOLFIRI + ramucirumab
Ramucirumab 8 mg/kg over 60 min, day 1
Repeat every 2 weeks

FOLFOXIRI 
Irinotecan 165 mg/m2 IV day 1, 
oxaliplatin 85 mg/m2 IV day 1,
leucovorin 400mg/m2 day 1, 
fluorouracil 1600 mg/m 2/d x 2 days (total 3200 mg/m2 over 48 hours) continuous infusion starting on day 1. 
Repeat every 2 weeks

FOLFOXIRI + bevacizumab
Bevacizumab 5 mg/kg IV, day 1
Repeat every 2 weeks

IROX
Oxaliplatin 85 mg/m2 IV, followed by irinotecan 200 mg/m2 over 30–90 minutes every 3 weeks