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Physical Pharmacy Laboratory > Colloidal Dispersion > Flashcards

Colloidal Dispersion Flashcards

1
Q

a bounded space or an exact
quantity of a material

A

system

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2
Q

consists of at least two phases with one or more dispersed phase (internal) contained in a single continuous (external) phase

A

dispersion

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3
Q

a distinct homogenous part of a system

A

phase

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4
Q

internal phase?

A

dispersed phase

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5
Q

external or continuous phase?

A

dispersion medium

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6
Q
  • diameter of particles < 1 nm
  • A.k.a. True Solutions (one-phase)
A

molecular dispersion

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7
Q
  • diameter of particles 1 to 500 nm
  • e.g. gelatin mixture, milk
A

colloidal dispersion

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8
Q
  • diameter of particles > 500 nm
  • Ex. Emulsions and suspensions
A

coarse dispersion

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9
Q

particle size of colloidal dispersions?

A

between 1 nm to 500 nm

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10
Q

can colloidal dispersions be resolved by ordinary microscope?

A

no

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11
Q

what microscopes can colloidal dispersions be seen under?

A

electron microscope

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12
Q

can colloidal dispersions pass through filter paper?

A

yes

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13
Q

can colloidal dispersions pass through semipermeable membranes?

A

no

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14
Q

what is a colloidal dispersion’s diffusion rate?

A

slow

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15
Q

examples of colloidal dispersions

A

jelly, polymers, milk, paint, cheese

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16
Q

surface area per unit W or V

A

specific surface

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17
Q
  • possess large specific surface
    gold sol: Red -> Blue (larger)
  • color related to particle size
    Sb and As trisulfides: Yellow -> Red (larger)
A

colloidal particles

18
Q

colloidal form of Pt

A

platinum black

19
Q

*More extended
→ greater Specific surface
→ greater interaction between
dispersed phase and dispersion medium

A

shape of colloidal particles

20
Q
  • Scattering of light by colloidal particles
  • widely used for determining MW of colloids
A

Faraday-Tyndall Effect

21
Q
  • Used to observe the size, shape, and
    structure of colloidal particles
  • Has higher resolution power than
    optical microscope
A

Electron microscope

22
Q

brownian movement, diffusion, osmotic pressure, sedimentation (settling), viscosity

A

kinetic properties of colloids

23
Q
  • random movement of colloidal particles
  • velocity increases with decreasing particle size
A

Brownian Movement

24
Q
  • spontaneous movement from high to low
    concentration until uniform system is achieved
  • a direct results of Brownian movement
A

Diffusion

25
Q

diffusion can be expressed through?

A

Fick’s First Law

26
Q

can be described by van’t Hoff equation

A

Osmotic Pressure

27
Q

Van’t Hoff Equation:

A

𝝅=𝒄𝑹𝑻

28
Q
  • velocity of sedimentation is given by Stoke’s law
A

Sedimentation (Settling)

29
Q
  • resistance to flow of a system under applied stress
  • more viscous →greater force to make it flow
  • affected by shape of particles
    e.g. SPHERICAL →less viscous
    LINEAR →more viscous
A

Viscosity

30
Q

pharmaceutical applications of colloids?

A

1.) hydrogels
2.) microparticles
3.) liposomes
4.) micelles

31
Q
  • a colloidal gel in which water is DM
  • used for
A

hydrogels

32
Q

uses for hydrogels

A

a) wound healing
b) scaffolds in tissue engineering
c) sustained-release of drugs

33
Q
  • developed as carriers for vaccines and
    anticancer drugs
  • increase efficiency of drug delivery,
    release and targeting
A

microparticles

34
Q

size of microparticles

A

(0.2 - 5 um)

35
Q

contains polymer 1 of microparticles

A

outer shell

36
Q

contains polymer 2 of dispersed drug

A

core

37
Q

consists of an outer membrane and an
inner liquid core

A

liposomes

38
Q

forms liposomes

A

phospholipids

39
Q

lipophilic compounds ->

A

lipophilic membrane

40
Q

hydrophilic compounds ->

A

hydrophilic core

41
Q
  • similar to liposomes but do not have inner liquid compartment
  • used for delivery of hydrophobic
    pharmaceuticals
A

micelles

Physical Pharmacy Laboratory (4 decks)

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