Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Applied Biochem > Collagen Structure and Function Pt 1 > Flashcards

Collagen Structure and Function Pt 1 Flashcards

1
Q

ECM

A

extracellular space filled with large network of macromolecules called _____

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

ECM is composed of

A

large repertoire of specialized ECM proteins with various properties assembled into an organized network/meshwork, in close association with producer cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Connective tissues -

A

Tissues with more ECM than cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Teeth/Bone are specialized:

A

mineralized connective tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Cartilage

A

proteoglycan rich specialized CT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Lamina Propria

A

beneath oral epithelium - composed of collagen fibers in a CT or Stromal Matrix (like dermis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Gingiva, periodontium: have a _______

A

stromal matrix containing collagen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Stroma:

A

cells embedded in matrix

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Major Componenets of Stromal Matrix

A

collagen embedded in polysaccharide gorund sibstnace of hyaluronan + proteoglycans/GAGs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

stromal cells

A

derived from mesodermal lineage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Fibroblasts secrete ____ in most connective tissues

A

ECM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

In specialized cells ____ secrete ECM

A

other fibroblast related cells (osteoblasts, chondrocytes, and odontoblasts)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

specialized matrix at interface of CT stroma and epithelium

A

basal lamina

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

basal lamina is tethered to underlying CT by

A

Type VII collagen fibrils

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

basement membrane refers to

A

basal lamina and collagen layer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Major proportion of bone, cartilage and teeth tissues is:

A

ECM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Function of ECM:

A

provide support/anchorage to cells, structurally stable material

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

ECM function in bone:

A

support, locomotion, calcium homeostasis, skeleton protects brain, internal organs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

ECM function in teeth:

A

Provides strenght, strucutre, resists shearing forces of chewing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

ECM function in Cartilage:

A

support, locomotion, resilient shock absorber, for compressive forces of moving and chewing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

ECM roles in addition to structure:

A

embryonic development, regulation of cell function, tissue repair, angiogenesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Composition of ECM in specific tissues is related to what

A

biomechanical requirements of the tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

ECM can be viewed as a

A

composite material

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Genes encode for a large variety of ECM components -

A

this is used to create the perfect ECM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

ECM of bones or teeth is

A

calcified and hard

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

ECM of cornea is

A

optically tranparent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

ECM of a tendon is

A

rope-like organizaiton of collagen gives tensile strenght in one direction

28
Q

Collagen (fibrillar) mechanical property:

A

tensile strength

29
Q

Proteoglycans mechanical property:

A

resiliance, resistance to compression

30
Q

Elastin (elastic fibers) mechanical properties:

A

elasticity/resilience

31
Q

Fibrillin-1 (microfibrils) mechanical Property

A

controlled elasticity

32
Q

Mineral (Hydroxyapatite) mechanical property

A

strength, hardness, but also brittleness

33
Q

Fibrous proteins can be what two functions:

A

structural or adhesive

34
Q

Structural Fibrous proteins of ECM

A

Collagen, elastin, fibrillins

35
Q

Adhesive Fibrous proteins of ECM

A

fibronectin, vitronectin, laminin, help attach cells to ECM

36
Q

GAGs

A

long polysaccharides consisting of repeating disaccharide units - often covalently linked to protein in the form of proteoglycans (form hydrated gel in which fibrous proteins embed - resists compression and aqueous phase permits diffusion of nutrients)

37
Q

Collagens are the main structural component of:

A

ECM

38
Q

Collagens are what percent of total protein mass in mammals

A

25%,90% in bone and dentin

39
Q

Collagens structure:

A

trimeric molecules consisting of three identical (homotrimeric) or non identical (heterotrimeric) polypeptide chains - Alpha Chains

40
Q

Collagen characterized by long stiff, ________________ with 3 A-chains wound around each other in a rope-like super-helix

A

triple-stranded helical structure

41
Q

All collagen molecules contain at least one triple helical region called ___________ whcih requries the presence of glycine every third AA

A

collagenous domain

42
Q

In the usual case the collagenous domain is Gly-X-Y, with X and Y being

A

proline and 4-hydroxyproline

43
Q

how many collagens have been identified?

A

28

44
Q

How many genes encode for the 28 collagens

A

42

45
Q

Collagens are divided into what two classes?

A

Firbrillar and NonFibrillar

46
Q

Collagen Polypeptide nomenclature: a1(II)

A

a1- alpha chain numbering
(ii) - collagen type

47
Q

Gene nomenclature: COL2A1

A

COL2 - collagen type
A1 - alpha chain number

48
Q

Type 2 collagen Trimer type

A

homotrimer
a1(II) polypeptide chains
COL2A1 - only gene name

49
Q

Type 1 Collagen Trimer Type

A

Heterotrimer
a1(I) x2
a2(I)
COL1A1 and COL1A2

50
Q

Type 6 Collagen Trimer Type

A

Heterotrimer
a1(VI)
a2(VI)
a3(VI)
COL6A1 and COL6A2 and COL6A3

51
Q

Fibrillar Collagens:

A

1, 2, 3, 5, 11, 24, and 27

52
Q

NonFibrillar Collagens:

A

4, 6, 7, 8, 9, 10, 12-23, 25, 26, 28

53
Q

Fibrillar Collagens have a Large Collagenous Domain

A

1000 amino acids

54
Q

Fibrillar Collagens assemble into higher order (polymeric) rod like structures called

A

collagen fibrils

55
Q

Fibrous collagen molecules arrange in quarter-stagger array giving

A

characteristic banding

56
Q

MAJOR fibrillar collagens are

A

1,2, 3

57
Q

Collagen fibrils (once formed) are crosslinked between what adjacent molecules to increase tensile strength)

A

lysines

58
Q

Type 1 collagen is mostly found in

A

tendon, bone, ligaments, dentin, skin

59
Q

Type 2 collagen is mostly found in

A

cartilage matrix

60
Q

Type 3 (with 5) is important in

A

dermal reticular fibers (small amounts also in dentin)

61
Q

Type 5 is associated with

A

type 1 - regulate the assembly of heterotypic fibers made of type 1 and 5

62
Q

Type 11

A

found in cartilage, eye, regulates spacing of type 2 collagen fibrils

63
Q

Mutations in type 1 collagen genes are assoc with

A

osteogenesis imperfecta

64
Q

90% of organic material in bone and teeth is

A

collagen type 1

65
Q
A

Applied Biochem (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions