Collagen Metabolism and Skeletal Biochemistry Flashcards
1
Q
What is the most abundant type of collagen?
A
Fibrillar
2
Q
How does collagen become assembled?
A
AA twist into Tropocollagen, and TC bind together extracellularly to make collagen fibrils –> Fibres
3
Q
What 2 bond types hold collagen together?
A
1) Covalent Cross-links (With and Between triple helix)
2) Hydrogen Bonds (Within TC)
4
Q
What enzyme breaks down Collagen?
A
Proteinase
5
Q
What are the 5 types of cartilage and function?
A
1) Bone tendon ligaments and skin
2) Cartilage
3) Reticulin and Liver/BM (Wound Healing)
4) Basement Membrane
5) Placenta
6
Q
What biochemical features are monitored for bone treatment?
A
1) Formation : P1NP/P1CP
2) Destruction: NTX/CTX
3) Mineralised Matrix: Bone Mass/Architecture
