Collagen

Question 1

What joins collagen together

Answer 1

Covalent cross links - needs copper. Within and between the triple helix/tropocollagen molecule

Hydrogen bonds - requires vitamin C

Between the tropocollagen molecules - pyridinolines

Question 2

What is collagen broken down by

Answer 2

Proteinases - proteins that digest proteins

Collagenases and Cathepsin K (in bone)

Question 3

Why is collagen broken down

Answer 3

Repair and replacement - where breakdown is balance by synthesis

OR

Pathological process

Question 4

Type 1

Answer 4

bone, tendon, ligaments, skin

Question 5

Type 2

Answer 5

Articular cartilage, vitreous

Question 6

Type 3

Answer 6

Alongside type 1 - wound healing

Question 7

Type 4

Answer 7

Basal lamina

Question 8

Type 5

Answer 8

Cell surfaces

Question 9

Type 10

Answer 9

Growth plate

Question 10

What type of collagen is most abundant in bone

Answer 10

Type 1

Question 11

What structure is common in all collagens

Answer 11

Triple helix

Question 12

What type of collagen is type 1

Answer 12

Fibrillar collagen

Molecular cross linking and fibril structure key to function

Question 13

What causes osteogenesis imperfecta

Answer 13

Mutations in collagen genes or genes that guid collagen synthesis

Question 14

How is bone disease diagnosed and monitored

Answer 14

Chemical-by product of collagen synthesis and breakdown