Colitis other Flashcards
1
Q
C diff colitis sx
Endoscopy
A
fever/leukocytosis
diarrhea
toxic megacolon
endoscopy: resembles UC (no chronicity, neutrophils)
Pseduomembranes
2
Q
C diff risk actors
A
immunocompromised host
antibiotics use
IBD
acid suppression
hospitalization
old age
3
Q
Rx of C diff colitis
A
- Metronidazole
PO Vancomycin
Refractory:
Long taper with vanco + other abx (rifaximin, fidaxomicin) - probiotics
- Fecal microbiome transplant
- toxin binders (cholestyramine)
4
Q
DDX of non-infectious colitis
A
- microscopic colitis
- eosinophilic colitis
- Baceht’s disease
- GVHD
- Neutropenic colitis (typhlitis)
- NSAIDS
- Solitary rectal ulcer
- Radiation colitis
- ischemic colitis
- Diversion colitis
5
Q
Acute GVHD
Organs involved
A
Acute <100 post HSCT
Skin: rash (palmes, soles)
GI: liver, diarrhea, nausea, vomiting, abdominal pain, bleeding, ileus
6
Q
Histology of acute GVHD
A
Apoptotic bodies in base of crypts
inflammatory cell infiltrates
crypt abscesses, loss of crypts
destruction of surface epithelium
7
Q
Rx of acute GVHD
A
1st line Steroids
2nd line: high dose steroids, cyclosporin, tacrolimus, MMD
