Colchicine

Question 1

What is colchicine?

Answer 1

A medication commonly used to treat gout with anti-inflammatory, anti-mitotic and anti-neutrophillic actions

Reduces **neutrophil **migration, chemotaxis adhesions and phagocytosis

Question 2

Indications for Colchicine?

Answer 2

Bechets, Sweets
LCV
EN
Neutrohillic rich immunobullous disease, EBA, LABD, DH
Chronic apthous ulcers / stomatitis
Amyloidosis

Question 3

Contraindications to Colchicine?

Answer 3

Hypersensitivity to a drug or a component

Blood dyscrasia
Severe, renal hepatic GI or cardiac disease

Pregnant or lactating - Cat D

Question 4

Dosage of colchicine?

Answer 4

0.5 - 0.6 mg orally
2 -3 times daily

Question 5

Side effects of colchicine?

Answer 5

Common:
- GI (diarrhea, abdominal pain, nausea, vomiting; dose-related)

Uncommon:
alopecia,
peripheral neuropathy,
myopathy
bone marrow suppression

multiorgan failure with acute overdose

Question 6

Baseline Ix for Colchicine?

Answer 6

FBC,
UEC,
CMP

Question 7

Monitoring guidelines

Answer 7

Repeat CBC monthly for several months then every 3 - 6 months