Bleomycin

Question 1

What is the MoA of Bleomycin?

Answer 1

used for treatment of verruca Vulgaris (viral warts)

inhibits DNA synthesis in infected keratinocytes, but
no direct effect on the human papillomavirus

Question 2

What is Bleomycin used for?

Answer 2

intralesional treatment of therapy-resistant verrucae
vulgaris; 65%–80% of lesions clear after 1 to 2 injections

Question 3

What is the doseage of Bleomycin?

Answer 3

0.1 to 0.3 ml of 1 U/ml (of saline) injected into targeted lesions, with

maximum total dose per treatment = 2 ml; (2 units)

repeated every 2 to 6 weeks until resolution;

given its rapid degradation and expense, newly constituted solution should be divided into glass vials and can be stored at 2–8°C for ~3 months

Question 4

Side effects of Bleomycin?

Answer 4

injection is extremely painful (local or regional anesthesia may be required);

pain and burning postinjection for 2–3 days;

Raynaud phenomenon occasionally;
nail dystrophy;
flagellate dermatitis (above recommended total dose);

no systemic toxicity with recommended total dose

Question 5

Pregnancy status of Bleomycin?

Answer 5

Category D, not recommended for lactating women eiuther

Question 6

What is Bleomycin?

Answer 6

A sulfur containing glycopeptide cytotoxic antibiotic derived from Streptomyces Verticillus

It has antitumour, antiviral and antibacterial acitivity

Question 7

Strategies to reduce pain with Bleomycin injections?

Answer 7

Pretreatment Local Anaesthetic
Reconstitution of bleomycin with a local anaesthetic

Ice packs
Vibration
Distraction