IL 12/ 23 and IL 23s

Question 1

List the IL 12 /23s and IL 23s

Answer 1

12/ 23
* Ustekinumab (stelara)

IL 23s:
* Rizankizumab (skyrizi)
* Tildrakizumab (Ilumya)
* Guselkinumab (Tremfya)

Question 2

Ustekinumab binds to the p19 subunit that is shared by the heterodimeric IL-12 and IL-23 cytokines

Answer 2

False - binds to the p40 subunit

Question 3

complete the sentance

Ustekinumab binds to…

Answer 3

the p40 subunit of Il12 / 23

Question 4

finish the sentance

Il-23s bind to the…

Answer 4

P19 subunit that is specifc to IL23

Question 5

Regarding IL 12 / 23, and IL 23s

What are the contraindications?

Answer 5

Hypersensitivity

Malignancy
Serious active infection

Question 6

Side effects of IL 12 / 23 and 23s?

Answer 6

Anaphylaxis or hypersensitivity

URTI
ISRs (5%)
Dermatophyte infections (1%)

Question 7

What is the dosing schedule for Guselkumab?

Answer 7

100mg s/c injection at:
Week 0
week 4
then 8 weekly

Question 8

What is the dosing schedule for Tildrakizumab?

Answer 8

100mg s/c injection
Week 0
week 4
then 12 weekly

Question 9

What is the dosing schedule for rizankizumab?

Answer 9

150 mg
Week 0
Week 4
Then 12 weekly

Question 10

Ustekinumab is associated with an excess of major adverse cardiac events

Answer 10

F - this was noted in clinical trials but not proven in a meta-analysis

Question 11

What is the generic name for skyrizi? and what type of blocker is it?

Answer 11

Rizankizumab

IL23

Question 12

What is the generic name for Stelara? and what is it?

Answer 12

Ustekinumab
IL 12 / 23

Question 13

What is the generic name of Tremfya? and what is it?

Answer 13

Guselkumab

IL 23

Question 14

What is the generic name of Ilumya? and what is it?

Answer 14

Tildrakizumab
IL 23