Cognitive Enchancers

Question 1

Donepezil

• Class
• Indications
• Dosing
• Side Effects

Answer 1

• Ach-ase inhibitors
• Mild to moderate dementia
• Once daily dosing
• Some GI side effects

Question 2

All of the Ach-ase inhibitors we use in dementia:

Answer 2

• Donepezil
• Galantamine
• Rivastigmine
• Tacrine

Question 3

Memantine

• Class
• Indications
• Dosing
• Side Effects

Answer 3

• NMDA antagonist
• Moderate to severe dementia
• Used together with an Ach-ase inhibitor
• Insomnia, agitation, but generally well tolerated.

Question 4

Drugs potentially used to treat Alzheimer’s =

Answer 4

- The cholinesterase inhibitors:
    • Donepezil
    • Galantamine
    • Rivastigimine
    • Tacrine

• Memantine